Assessment of Cortical Interruptions in the Finger Joints of Patients With Rheumatoid Arthritis Using HR-pQCT, Radiography, and MRI

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
M PetersJoop van den Bergh

Abstract

Small cortical interruptions may be the first sign of an erosion, and more interruptions can be found in patients with rheumatoid arthritis (RA) compared with healthy subjects. First, we compared the number and size of interruptions in patients with RA with healthy subjects using high-resolution peripheral quantitative CT (HR-pQCT). Second, we investigated the association between structural damage and inflammatory markers on conventional radiography (CR) and MRI with interruptions on HR-pQCT. Third, the added value of HR-pQCT over CR and MRI was investigated. The finger joints of 39 patients with RA and 38 healthy subjects were examined through CR, MRI, and HR-pQCT. CRs were scored using the Sharp/Van der Heijde method. MRI images were analyzed for the presence of erosions, bone marrow edema, and synovitis. HR-pQCT images were analyzed for the number, surface area, and volume of interruptions using a semiautomated algorithm. Descriptives were calculated and associations were tested using generalized estimating equations. Significantly more interruptions and both a larger surface area and the volume of interruptions were detected in the metacarpophalangeal joints of patients with RA compared with healthy subjects (median, 2.0, 1...Continue Reading

References

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Nov 8, 2013·Rheumatology·Piet Geusens, Joop van den Bergh
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Nov 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roger Zebaze, Ego Seeman
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Citations

Oct 28, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Q PangL Qin
Jul 2, 2020·Expert Opinion on Pharmacotherapy·Hennie G RatermanWillem F Lems
Dec 15, 2019·Journal of Clinical Medicine·Lena HirtlerFranz Kainberger
May 6, 2021·Therapeutic Advances in Musculoskeletal Disease·Edoardo CipollettaEmilio Filippucci
May 24, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J P van den BerghR Chapurlat
Jul 7, 2021·Autoimmunity Reviews·Tsutomu TakeuchiSakae Tanaka

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