Assessment of CPM reliability: quantification of the within-subject reliability of 10 different protocols

Scandinavian Journal of Pain
Henrik Bjarke VaegterLars Arendt-Nielsen

Abstract

Background and aims Conditioned Pain Modulation (CPM) is a well-established phenomenon and several protocols have shown acceptable between-subject reliability [based on intraclass correlation coefficient (ICC) values] in pain-free controls. Recently, it was recommended that future CPM test-retest reliability studies should explicitly report CPM reliability based on CPM responders and non-responders (within-subject reliability) based on measurement error of the test stimulus. Identification of reliable CPM paradigms based on responders and non-responders may be a step towards using CPM as a mechanistic marker in diagnosis and individualized pain management regimes. The primary aim of this paper is to investigate the frequency of CPM responders/non-responders, and to quantify the agreements in the classification of responders/non-responders between 2 different days for 10 different CPM protocols. Methods Data from a previous study investigating reliability of CPM protocols in healthy subjects was used. In 26 healthy men, the test-stimuli used on both days were: Pain thresholds to electrical stimulation, heat stimulation, manual algometry, and computer-controlled cuff algometry as well as pain tolerance to cuff algometry. Two diff...Continue Reading

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Feb 12, 2005·Journal of Strength and Conditioning Research·Joseph P Weir
Jan 12, 2007·Pain·Philippe GoffauxSerge Marchand
Sep 18, 2012·The Journal of Pain : Official Journal of the American Pain Society·Gwyn N LewisPeter J McNair
Oct 1, 2013·Pain·Henrik Bjarke VaegterThomas Graven-Nielsen
Nov 26, 2013·Pain·David YarnitskyYelena Granovsky
Dec 23, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Henrik Bjarke VaegterThomas Graven-Nielsen
Aug 16, 2016·The Clinical Journal of Pain·Caitríona FingletonCatherine M Doody
Oct 19, 2016·Pain·Donna L KennedyAndrew S C Rice

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Citations

Jan 22, 2019·Expert Review of Clinical Pharmacology·Louise KuhlmannAsbjørn M Drewes
Jan 10, 2019·Pain·Hadas Nahman-AverbuchRobert C Coghill
Mar 29, 2019·Scandinavian Journal of Pain·Jesper Bie LarsenLars Arendt-Nielsen
Jul 26, 2019·European Journal of Pain : EJP·Morten HoeghThomas Graven-Nielsen
Jul 22, 2020·Scandinavian Journal of Pain·Lars Arendt-NielsenPascal Madeleine
Feb 27, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Alberto Arribas-RomanoMarcos José Navarro-Santana
Sep 24, 2020·European Journal of Pain : EJP·Michel Gcam MertensMira Meeus
Jul 9, 2021·Current Rheumatology Reports·Felipe C K DuarteDinesh A Kumbhare

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