Assessment of cutaneous photosensitivity of TOOKAD (WST09) in preclinical animal models and in patients

Photochemistry and Photobiology
Robert A WeersinkBrian C Wilson

Abstract

TOOKAD (WST09) is a new, long-wavelength palladium bacteriopheophorbide photosensitizer that targets tissue vasculature. The cutaneous phototoxicity of TOOKAD was assessed in normal rat and pig animal models and in patients in a Phase-I trial of TOOKAD-mediated photodynamic therapy (PDT) for recurrent prostate cancer. Controlled skin exposures were administered using solar-simulated light at various times after drug administration. Two different spectral ranges were used. In the first, the UV portion of the spectrum was removed (UV(-)) because UV irradiation in nondrugged control animals produced an erythema response at incident energy densities (J/cm(2)) lower than those required to induce a PDT response. In the second, the full solar spectrum (UV(+)) was used, and the potentiation by the photosensitizer of the UV-mediated minimum erythema dose was assessed. Results showed that the PDT skin response was negligible at clinical drug doses of 2 mg/kg for any period after administration at light doses of 128 J/cm(2) in the animal models. In patients, there was no observed UV(-) skin response at doses of up to 2 mg/kg, drug-light intervals of 1-3 h or greater and light exposures up to 128 J/cm(2). At higher drug doses in the rat an...Continue Reading

Citations

Nov 30, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Zheng HuangFred W Hetzel
Sep 13, 2012·Physics in Medicine and Biology·Andreea DimofteTimothy C Zhu
Sep 29, 2018·Health Technology Assessment : HTA·Freddie C HamdyTom A Leslie
Apr 22, 2017·Oncotarget·Taher GheewalaGnanasekar Munirathinam

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