PMID: 8986490Dec 1, 1996Paper

Assessment of depth of midazolam sedation using objective parameters

Intensive Care Medicine
C HaberthürR Ritz

Abstract

To determine the relationship between the clinically evaluated depth of midazolam-induced sedation and the cardiac beat-to-beat variability (RR variability) in ICU patients in the intensive care unit (ICU). Prospective study. ICU of a university hospital. 20 consecutive patients studied during weaning from mechanical ventilation and withdrawal of midazolam-induced sedation. After clinical evaluation of depth of sedation according to the Ramsay sedation score, the RR variability over 512 RR intervals and predominant respiratory rate were measured. The power spectrum of RR variability was calculated by a fast Fourier transformation and the resulting total frequency band (0.016-0.35 Hz) was subdivided into a very low, a low, and a high frequency band. Stepwise multiple regression analysis in the first 10 patients (group 1) showed a significant relationship between depth of sedation and measures of RR variability combined with respiratory rate (r2 = 0.59; F = 12.1; p < 0.001). The more effective sedation was, the more depressed were both RR variability and predominant respiratory rate. Mean heart rate, mean respiratory rate, median deviation of RR intervals from the mean, and the ratio between spectral power density in the high and...Continue Reading

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Sep 27, 2007·Neurocritical Care·Daiwai OlsonCarmelo Graffagnino
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