Assessment of DNA damage in postmenopausal women under osteoporosis therapy

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Merih BayramSemra Sardas

Abstract

The following study was designed to examine possible DNA damage levels in peripheral blood leukocytes, using the alkaline Comet assay, isolated from postmenopausal women undergoing osteoporosis treatment. Thirty-two postmenopausal women were randomized into two groups of 16. A dosage of 2.5 mg/day of tibolone (Livial) and 10mg/day of alendronate sodium (Fosamax) were administered to Group 1 over a 12-month period while Group 2 took 10 mg/day of alendronate alone over the same period. The control group consisted of 16 postmenopausal women who did not receive any treatment. Genotoxicity was assessed by the standard method of alkaline Comet assay. When the results of the study groups were compared with those of the control group, significant differences in terms of DNA damage levels were found (p<0.05). However, no difference was detected between Groups 1 and 2 (p>0.05). Although, no statistical difference in terms of DNA damage levels between tibolone plus alendronate as opposed to alendronate alone was found, an increase in DNA damage levels was observed in Groups 1 and 2 compared with the control group. Consequently, it can be asserted that the frequency of DNA damage in postmenopausal women with osteoporosis increases under al...Continue Reading

References

Feb 1, 1995·Maturitas·L A Ross, E M Alder
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S AdamiS Ortolani
Jul 1, 1996·The Journal of Clinical Endocrinology and Metabolism·N H BjarnasonC Christiansen
Apr 26, 2000·British Journal of Cancer·S G SenaratneK W Colston
Oct 25, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F I SahinO F Saraçoğlu
May 18, 2001·Biochemical Society Transactions·A R Collins, E Horváthová
Jan 17, 2002·Pharmacotherapy·Cees J Timmer, Natalie S Houwing
Dec 23, 2003·Carcinogenesis·Olga I KalantziFrancis L Martin

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