Assessment of DNA damage in WBCs of workers occupationally exposed to fumes and aerosols of bitumen

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
B MarczynskiT Brüning

Abstract

We conducted a cross-shift study with 66 bitumen-exposed mastic asphalt workers and 49 construction workers without exposure to bitumen. Exposure was assessed using personal monitoring of airborne bitumen exposure, urinary 1-hydroxypyrene (1-OHP), and the sum of 1-, 2 + 9-,3-,4-hydroxyphenanthrene (OHPH). Genotoxic effects in WBC were determined with nonspecific DNA adduct levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and the formation of DNA strand breaks and alkali-labile sites. Concentration of fumes and aerosols of bitumen correlated significantly with the concentrations of 1-OHP and OHPH after shift (r(s) = 0.27; P = 0.03 and r(s) = 0.55; P < 0.0001, respectively). Bitumen-exposed workers had more DNA strand breaks than the reference group (P < 0.0001) at both time points and a significant correlation with 1-OHP and OHPH in the postshift urines (r(s) = 0.32; P = 0.001 and r(s) = 0.27; P = 0.004, respectively). Paradoxically, we measured higher levels of DNA strand breaks, although not significant, in both study groups before shift. 8-OxodGuo adduct levels did not correlate with DNA strand breaks. Further, 8-oxodGuo levels were associated neither with personal exposure to bitumen nor with urinary metabolite conc...Continue Reading

References

Jan 1, 1992·International Archives of Occupational and Environmental Health·S BurgazF J Jongeneelen
Jul 1, 1991·Chemical Research in Toxicology·F P Guengerich, T Shimada
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Jan 1, 1987·International Archives of Occupational and Environmental Health·S MonarcaG Angeli
Apr 16, 1984·Biochemical and Biophysical Research Communications·E Ling, V Sapirstein
Nov 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M L MachadoE L McGinnis
May 1, 1996·Environmental Health Perspectives·A R CollinsR Stĕtina
Jan 1, 1996·International Archives of Occupational and Environmental Health·J FuchsF Oesch
Nov 7, 1998·Mutation Research·S BurgazA E Karakaya
Mar 6, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·E RojasM Valverde
Mar 31, 1999·Free Radical Research·C M GedikA R Collins
Jun 9, 1999·Scandinavian Journal of Work, Environment & Health·B JärvholmC Bergendahl
Oct 8, 1999·Toxicology Letters·C ViauK Krishnan
Mar 23, 2001·Journal of Toxicology and Environmental Health. Part a·J MajorA Tompa
Sep 21, 2001·International Archives of Occupational and Environmental Health·M ToraasonT M Reid
Nov 7, 2001·Journal of Environmental Monitoring : JEM·L G EkströmD Breuer
Mar 8, 2003·International Journal of Hygiene and Environmental Health·Kerstin BeckerBernd Seifert
Apr 11, 2003·The Science of the Total Environment·S BinetM Castegnaro
Nov 1, 2003·Journal of Environmental Monitoring : JEM·Virpi VäänänenPirjo Heikkilä
Nov 26, 2003·Mutation Research·Geir SlupphaugHans E Krokan
Mar 3, 2004·Archives of Biochemistry and Biophysics·Andrew R CollinsJose Viña
Aug 5, 2004·The Annals of Occupational Hygiene·M D McCleanR F Herrick

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Citations

Mar 5, 2011·Archives of Toxicology·Monika Raulf-HeimsothThomas Brüning
Jun 24, 2008·Journal of Toxicology and Environmental Health. Part a·Monika Raulf-HeimsothThomas Brüning
Jun 30, 2009·Journal of Occupational and Environmental Hygiene·Thomas BehrensWolfgang Ahrens
Jul 16, 2009·The Annals of Occupational Hygiene·Jon R SobusStephen M Rappaport
Jun 13, 2012·Journal of Toxicology and Environmental Health. Part a·Benjamin KendziaMonika Raulf-Heimsoth
Feb 16, 2010·International Journal of Hygiene and Environmental Health·Hung-Hsin LiuHsiu-Ling Chen
May 24, 2008·Mutation Research·Hanna K LindbergHannu Norppa
Nov 6, 2010·Regulatory Toxicology and Pharmacology : RTP·Ceinwen A Schreiner
May 4, 2013·International Journal of Environmental Health Research·Aysegul BacaksizTulin Soylemezoglu
Oct 22, 2016·Environmental Health : a Global Access Science Source·Berrin SerdarRyan Gan
Apr 22, 2015·The International Journal of Occupational and Environmental Medicine·M NeghabJ Hassanzadeh
Nov 3, 2017·Critical Reviews in Toxicology·Anthony J KriechAnthony J Riley
Sep 15, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Beate PeschThomas Brüning

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