Assessment of dose reconstruction errors in image-guided radiation therapy

Physics in Medicine and Biology
Hualiang ZhongJeffrey V Siebers

Abstract

Dose reconstruction can be used to improve the accuracy of dose evaluation throughout a treatment course. Its working mechanism is based on deformable image registration (DIR). The purpose of this paper is to develop a method to estimate the dose reconstruction error associated with the inaccuracy of DIR algorithms. To reach this goal, we quantified dominant errors in DIR in terms of unbalanced energy (UE), which were compared with the standard displacement error (SDE). Their high similarity, characterized by Pearson correlation coefficient, was verified through nine 'demons' registration instances performed within simulated reference frames. Based on the similarity, the dose-warping discrepancy at each voxel was defined as a line integral of the dose gradient within the voxel's neighborhood whose boundary was determined by the voxel's UE value. From this definition, the dose reconstruction error was then calculated at each voxel on nine prostate computed tomography images, obtained from a patient treatment course. The average of the Pearson correlation coefficients between UE and SDE over the simulated registration instances was above 70%. The mean value of the dose reconstruction errors in a target volume was calculated for e...Continue Reading

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Citations

Sep 11, 2009·Physics in Medicine and Biology·Hualiang Zhong, Jeffrey V Siebers
May 15, 2012·Physics in Medicine and Biology·Hualiang ZhongIndrin J Chetty
Apr 10, 2012·Medical Physics·U J YeoR D Franich
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Apr 17, 2013·Physics in Medicine and Biology·M Hub, C P Karger
Sep 5, 2013·Physics in Medicine and Biology·Shunshan LiHualiang Zhong

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