Jan 15, 2019

Assessment of doxorubicin delivery devices based on tailored bare polycaprolactone against glioblastoma

International Journal of Pharmaceutics
Enrique NizaAntonio Otero

Abstract

Bare polycaprolactones with controlled molar mass and dispersity were employed to manufacture biodegradable devices, which were applied for doxorubicin delivery in glioblastoma. Micro- and nanoscale devices were prepared by emulsion formation or by a combination of precipitation and hydrolysis. The carriers were characterized by scanning electron microscopy, dynamic light scattering techniques, thermogravimetric analysis and differential scanning calorimetry. The encapsulation parameters and drug-release profiles are discussed in order to evaluate the influence of different fundamental parameters, such as molar mass and dispersity value, pH, morphology or crystallinity, on the efficiency of the doxorubicin delivery systems. The ability of doxorubicin-loaded micro- and nanoscale devices to induce cellular toxicity in glioblastoma cells was also explored. A cell viability assay against C6 cells of doxorubicin-loaded nanocarriers showed higher cytotoxicity than doxorubicin-loaded microcarriers. In addition, doxorubicin-loaded nanocarriers also showed good antitumor profile in human tumoral cells and improved the security profile in relation to free doxorubicin in non-tumoral cells. Consistent with the assessment study described in...Continue Reading

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Mentioned in this Paper

Doxorubicin
Glioblastoma Multiforme
Macrophages, Peritoneal
Study
Tumor Cells, Uncertain Whether Benign or Malignant
Polycaprolactone
Drug Carriers
Polyesters
Drug Delivery Systems
Neoplastic Cell

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