Assessment of drug-drug interaction in an elderly human immunodeficiency virus population: Comparison of 3 expert databases.

British Journal of Clinical Pharmacology
Anne-Lise RuellanClotilde Allavena

Abstract

Polypharmacy increase the risk of drug-drug interactions (DDIs) in the elderly population living with human immunodeficiency virus (HIV). Several expert databases can be used to evaluate DDIs. The aim of the study was to describe actual DDIs between antiretroviral drugs and comedications in an elderly population and to compare grading of the DDIs in 3 databases. All treatments of HIV-infected subjects aged 65 years and older were collected in 6 French HIV centres. Summary of Product Characteristic (SPC), French DDI Thesaurus (THES), and Liverpool HIV DDI website (LIV) were used to define each DDI and specific grade. DDIs were classified in yellow flag interaction (undefined grade in SPC and THES or potential weak interaction in LIV), amber flag interaction (to be considered/precaution of use in SPC and THES and potential interaction in LIV) and red flag interaction (not recommended/contraindication in SPC and THES and do not administer/contraindication in LIV). Among 239 subjects included, 60 (25.1%) had at least 1 DDI for a total of 126 DDIs: 23/126 red flag DDIs were identified in 17 patients. All these 23 DDIs were identified in LIV. THES and SPC missed 6 and 1 red flag DDIs, respectively. Seven of 23 red flag DDIs were iden...Continue Reading

References

Feb 1, 1988·Journal of the American Geriatrics Society·L Nolan, K O'Malley
Jun 18, 2011·The Journal of Antimicrobial Chemotherapy·Catia MarzoliniUNKNOWN Swiss HIV Cohort Study Members
Oct 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Giovanni GuaraldiFrank Palella
Dec 25, 2013·PloS One·Hasina SamjiUNKNOWN North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA
Dec 23, 2014·European Journal of Clinical Pharmacology·Tina RoblekMitja Lainscak
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderUNKNOWN CGTP Collaborators
Sep 13, 2016·Clinical Interventions in Aging·Mercedes Gimeno-GraciaMaría José Rabanaque-Hernández
Nov 11, 2016·AIDS·Aysel GuelerUNKNOWN Swiss HIV Cohort Study, Swiss National Cohort
Feb 6, 2017·Clinical Pharmacology and Therapeutics·D M BurgerD J Back
Jun 13, 2017·The Journal of Antimicrobial Chemotherapy·Silvia NozzaUNKNOWN GEPPO Study Group
Aug 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beatriz López-CentenoJuan Berenguer
Oct 18, 2019·Therapeutic Advances in Drug Safety·Françoise Livio, Catia Marzolini

❮ Previous
Next ❯

Citations

May 29, 2021·Expert Opinion on Drug Safety·Camilla Ingrid HatlebergCaroline Sabin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Pharmacological Sciences
Bethany Percha, Russ B Altman
Journal of Young Pharmacists : JYP
Uv MatetiP Ramachandran
The Annals of Pharmacotherapy
Ingeborg K BjörkmanPharmaceutical Care of the Elderly in Europe Research (PEER) Group
Perspectives in Clinical Research
Saibal DasSandhiya Selvarajan
© 2021 Meta ULC. All rights reserved