Assessment of dynamic contrast enhancement of the small bowel in active Crohn's disease using 3D MR enterography

European Journal of Radiology
Patrick R KnueselJohannes M Froehlich

Abstract

To retrospectively compare the dynamic contrast enhancement of the small bowel segments with and without active Crohn's disease at 3D MR enterography (MRE). Thirteen patients (five men, eight women; mean age 41.2 years; range 29-56) were imaged on a 1.5-T MR scanner (Sonata, Siemens Medical) with standard MR sequences after having ingested 1000 ml of a 3% mannitol solution. Subsequently, high resolution 3D gradient-echo (volumetric interpolated breath-hold examination=VIBE) data sets were obtained pre-contrast and 20-40s, 60-80s, and 120-140 s after i.v. Gd-DOTA administration (0.2 mmol/kg). Signal enhancement was measured on single slices both in normal and histologically confirmed (12/13) inflamed small bowel wall segments as well as in the aorta, the psoas muscle, and the background to calculate signal-to-noise (SNR) and contrast-to-noise ratios (CNR). Small bowel wall enhancement was significantly higher (p<0.05) in inflamed compared to normal segments at 20-40s (SNR inflamed: 58.7+/-33.8 vs normal: 36.0+/-19.8; p=0.048; CNR inflamed: 34.8+/-23.4 vs normal: 16.3+/-11.2; p=0.017) and at 60-80s (SNR: 60.3+/-25.1 vs 41.9+/-20.0; p=0.049; CNR: 34.9+/-15.1 vs 19.3+/-13.2; p=0.01) after i.v. contrast administration, respectively....Continue Reading

References

Jul 1, 1993·Journal of Clinical Gastroenterology·J P ShoenutA B Micflikier
May 24, 2000·Abdominal Imaging·F MaccioniP Rossi
May 16, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M BoudiafR Rymer
Feb 26, 2003·Radiology·Walter WiesnerPablo R Ros
Jul 30, 2003·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·S PaulsA Gabelmann
Mar 6, 2004·Scandinavian Journal of Gastroenterology·G L RapacciniG Gasbarrini
Apr 2, 2004·European Radiology·Nicholas GourtsoyiannisMaria Roussomoustakaki
Jul 1, 2005·Digestive Diseases and Sciences·Bart M WiardaHans A R E Tuynman

❮ Previous
Next ❯

Citations

Feb 8, 2011·Current Opinion in Gastroenterology·Ellen M Zimmermann, Mahmoud M Al-Hawary
Jun 4, 2014·Radiologic Clinics of North America·Brian C Allen, John R Leyendecker
Mar 18, 2015·Abdominal Imaging·Jeffrey S QuonNicola Schieda
Jul 24, 2014·Inflammatory Bowel Diseases·Kathryn J FowlerConstantine Raptis
Dec 17, 2010·World Journal of Radiology·Arda KayhanAytekin Oto
Sep 1, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A KhalafG W Moran
Jun 9, 2012·Current Opinion in Gastroenterology·Mahmoud Al-Hawary, Ellen M Zimmermann
Aug 8, 2015·Journal of Magnetic Resonance Imaging : JMRI·Emilio QuaiaMaria Assunta Cova
May 29, 2013·Journal of Magnetic Resonance Imaging : JMRI·Joseph H YacoubAytekin Oto
Jul 23, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S A FallisS Sanders

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.