Assessment of early-life lead exposure in rural Bangladesh

Environmental Research
Charlotte BergkvistMarie Vahter

Abstract

Lead is a well-known neurotoxic metal and one of the most toxic chemicals in a child's environment. The aim of this study was to assess early-life lead exposure in a pristine rural area of Bangladesh. The exposure was expected to be very low because of the absence of vehicle traffic and polluting industries. Lead was measured in erythrocytes, urine, and breast milk of 500 randomly selected pregnant women, participating in a randomized food and micronutrient supplementation trial in Matlab (MINIMat). Lead was also measured in urine of their children at 1.5 and 5 years of age, and in rice, well water, cooking pots, and materials used for walls and roof. All measurements were performed using ICPMS. We found that the women had relatively high median erythrocyte lead levels, which increased considerably from early pregnancy to late lactation (81-136microg/kg), probably due to release from bone. Urinary lead concentrations were unchanged during pregnancy (median approximately 3.5microg/L) and non-linearly associated with maternal blood lead levels. Children, at 1.5 and 5 years of age, had a median urinary lead concentration of 4microg/L, i.e., similar to that in their mothers. Rice, the staple food in Matlab, collected from 63 homes ...Continue Reading

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Citations

May 17, 2013·American Journal of Epidemiology·Renee M GardnerMarie Vahter
May 2, 2012·Pharmacogenetics and Genomics·Renee M GardnerMarie Vahter
Dec 3, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Helena M SkröderMaria J Kippler
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Oct 4, 2011·Environmental Research·Marika BerglundMarie Vahter
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Dec 24, 2011·Environmental Research·Maria KipplerKarin Broberg
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Aug 5, 2014·The Science of the Total Environment·Jeffrey D WeidenhamerPerry Gottesfeld
May 4, 2012·Chemosphere·Charlotte BergkvistMarie Vahter
Aug 16, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Judita Grzunov LetinićTatjana Orct
Oct 21, 2016·Environmental Research·Helena SkröderMarie Vahter
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Nov 9, 2017·Environmental Health Perspectives·Helena SkröderMarie Vahter
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Sep 19, 2019·Environmental Science & Technology·Jenna E ForsythStephen P Luby
Aug 27, 2021·Journal of Health & Pollution·Ahmad Kamruzzaman MajumderWilliam S Carter

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