Abstract
Recent ecological studies have suggested a possible association between exposure to ultraviolet-B (UVB) radiation and reduction in the risk of various cancers; however, ecological studies are known to be subject to bias. The objective of this study was to demonstrate difficulties with the ecological approach. We conducted a multicountry ecological study using cancer incidence rates, residential UV levels, dietary intake, and different sociodemographic variables for 38 locations spanning 33 countries worldwide. The effect of residential UV exposure on cancer incidence was assessed using multiple linear regression models. The results of our multivariate analyses show no indication of an inverse association between residential UV levels and the risk of colon, non-Hodgkin's lymphoma (NHL), ovarian, prostate, or breast cancer in women. For colon cancer and NHL, a significant positive association was calculated. The rates of melanoma, which were used to examine the methods of this study, showed a strong and significant (P<0.01) association with solar radiation. Our results provide no evidence to support previous ecological results that UV exposure may reduce the risk of NHL, colon, breast, ovary, or prostate cancer. The study demonst...Continue Reading
References
Feb 12, 1988·Science·J ScottoT Fears
Sep 1, 1985·American Journal of Epidemiology·S Greenland, J M Robins
Dec 1, 1994·International Journal of Epidemiology·E S Lefkowitz, C F Garland
Dec 1, 1993·Environmental Health Perspectives·H Morgenstern, D Thomas
Oct 24, 2000·Clinical and Experimental Dermatology·R Marks
Jan 30, 2002·Cancer·William B Grant
Jan 10, 2003·Journal of Cellular Biochemistry·Michael F Holick
Jun 6, 2003·Oncogene·Margaret A Tucker, Alisa M Goldstein
Feb 18, 2004·Archives of Dermatology·Elisabeth ThiedenHans Christian Wulf
Mar 24, 2004·European Urology·William B Grant
Jun 29, 2004·Journal of Surgical Oncology·William H McCarthy
Aug 24, 2004·Oncogene·Donald M Parkin
Mar 31, 2005·Endocrine Reviews·Sunil NagpalRadhakrishnan Rathnachalam
Nov 24, 2005·International Journal of Epidemiology·Cedric F Garland, Frank C Garland
Jan 31, 2006·Journal of the American Academy of Dermatology·Deon Wolpowitz, Barbara A Gilchrest
Apr 6, 2006·Progress in Biophysics and Molecular Biology·Anne Kricker, Bruce Armstrong
May 9, 2006·Urologic Oncology·Janet Laura Colli, Albert Colli
Aug 15, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H J van der RheeJ W W Coebergh
Jan 19, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Alina PorojnicuJohan Moan
Citations
May 1, 2012·Cancer Causes & Control : CCC·Kin-Yoke WongAdeline Seow
Jun 5, 2010·The British Journal of Nutrition·Margaret AshwellDavid Fraser
Mar 12, 2009·Pancreas·Rachel E NealeJolieke C van der Pols
Oct 13, 2011·Advances in Preventive Medicine·Krishna Vanaja Donkena, Charles Y F Young
Sep 16, 2009·Journal of the American Academy of Dermatology·Martin A Weinstock, Arnold M Moses
Sep 5, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Han van der RheeEsther de Vries
Jun 20, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·William B Grant
Jan 6, 2009·Internal Medicine Journal·R E NealeJ C van der Pols
Jun 29, 2011·International Journal of Cancer. Journal International Du Cancer·Masaaki TodaTakuma Kato
Mar 17, 2015·International Journal of Dermatology·Jerry D BrewerClark C Otley
Mar 17, 2010·American Journal of Obstetrics and Gynecology·Linda S CookRobert C Lee
Feb 18, 2011·Gynecologic Oncology·Lu YinHermann Brenner
Jul 30, 2014·BMC Public Health·Jennifer YuMarie-Élise Parent
Jun 20, 2012·World Journal of Experimental Medicine·Jiao Wang, Yang-Fu Jiang
Dec 20, 2013·Cancers·Jennifer PrescottShelley S Tworoger
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marit Bragelien VeierødElisabete Weiderpass
Sep 10, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Pierre EngelFrançoise Clavel-Chapelon