Assessment of ecotoxicological effects of ciprofloxacin in Daphnia magna: life-history traits, biochemical and genotoxic effects

Water Science and Technology : a Journal of the International Association on Water Pollution Research
Bruno NunesSara C Antunes

Abstract

Antibiotics (e.g. ciprofloxacin) have been detected in surface water and groundwater for several decades. In order to understand the potential impact of the continuous exposure of aquatic organisms to ciprofloxacin, a chronic assay was carried out with Daphnia magna. This approach allowed evaluation of the effects of ciprofloxacin on life-history and sub-individual parameters (antioxidant status and metabolic response: activities of catalase and glutathione S-transferases - GSTs; peroxidative damage; thiobarbituric acid reactive substances and genotoxic effects (genetic damage index, measured by the comet assay). Life-history parameters of D. magna showed no significant effects after ciprofloxacin exposure. Concerning oxidative stress and metabolism parameters, no significant alterations were reported for catalase and GSTs activities. However, a dual response was observed, with a significant decrease in lipid peroxidation levels at low ciprofloxacin concentrations (<0.013 mg/L), while a significant increase was verified at high ciprofloxacin concentrations (0.078 mg/L). The genotoxicity assay detected a significant increase in genetic damage index up to 0.013 mg/L of ciprofloxacin. The here-tested ciprofloxacin concentrations, ...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Feb 1, 1984·Biochemical Pharmacology·M Ogata, H Aikoh
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R Couper
Jan 15, 1999·Archives of Environmental Contamination and Toxicology·A HartmannR M Widmer
Dec 11, 1999·Environmental Health Perspectives·C G Daughton, T A Ternes
Sep 2, 2000·The Journal of Antimicrobial Chemotherapy·B Halling-SørensenF Ingerslev
Oct 24, 2001·Mutation Research·B A HerboldH J Ahr
Mar 23, 2002·The Journal of Antimicrobial Chemotherapy·Richard Wise
Jul 11, 2002·Mutation Research·A T Natarajan
Nov 26, 2003·Environmental Pollution·Sara C AntunesFernando Gonçalves
Aug 25, 2004·Water Research·Alexander KronimusRalf Littke
Apr 1, 1952·Proceedings of the National Academy of Sciences of the United States of America·A D Conger, L M Fairchild
Oct 22, 2008·Toxicology and Applied Pharmacology·Maqusood AhamedYiling Hong
Dec 27, 2008·Environmental Pollution·Shannon L Bartelt-HuntKyle Hoagland
Jan 20, 2009·Water Science and Technology : a Journal of the International Association on Water Pollution Research·P de VoogtM Mons
Feb 3, 2009·Chemosphere·Klaus Kümmerer
Dec 4, 2009·Journal of Hazardous Materials·Lúcia H M L M SantosM C B S M Montenegro
May 12, 2010·Journal of Hazardous Materials·Ettore ZuccatoRoberto Fanelli
Jun 11, 2010·Chemistry & Biology·Yves PommierChristophe Marchand
Sep 3, 2010·Nature Reviews. Drug Discovery·Bashar Hamad
Dec 27, 2012·The World Allergy Organization Journal·Esra BirbenOmer Kalayci
Feb 15, 2014·Aquatic Toxicology·Michal GalusJoanna Y Wilson
Dec 17, 2014·Ecotoxicology and Environmental Safety·Mirco Dalla BonaMarco De Liguoro
Nov 18, 2017·Oxidative Medicine and Cellular Longevity·Krzysztof MichalakBogusław Sobolewski

❮ Previous
Next ❯

Citations

Oct 2, 2020·Environmental Toxicology and Pharmacology·Ana Filipa Nogueira, Bruno Nunes
Jan 15, 2021·Environmental Science and Pollution Research International·Sara RodriguesSara Cristina Antunes
Jun 22, 2021·Journal of Water and Health·Sabrine AfsaHedi Ben Mansour
Aug 26, 2021·Water Environment Research : a Research Publication of the Water Environment Federation·Dafna ElukRafael Althaus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.