Assessment of Effectiveness of 1 Dose of BNT162b2 Vaccine for SARS-CoV-2 Infection 13 to 24 Days After Immunization.

JAMA Network Open
Gabriel ChodickK. Muhsen

Abstract

The BNT162b2 vaccine showed high efficacy against COVID-19 in a phase III randomized clinical trial. A vaccine effectiveness evaluation in a real-world setting is needed. To assess the short-term effectiveness of the first dose of the BNT162b2-vaccine against SARS-CoV-2 infection 13 to 24 days after immunization in a real-world setting. This comparative effectiveness study used data from a 2.6 million-member state-mandated health care system in Israel. Participants included all individuals aged 16 years and older who received 1 dose of the BNT162b2 vaccine between December 19, 2020, and January 15, 2021. Data were analyzed in March 2021. Receipt of 1 dose of the BNT162b2 vaccine. Information was collected regarding medical history and positive SARS-CoV-2 polymerase chain reaction test and COVID-19 symptoms from 1 day after first vaccine to January 17, 2021. Daily and cumulative infection rates in days 13 to 24 were compared with days 1 to 12 after the first dose using Kaplan-Meier survival analysis and generalized linear models. Data for 503 875 individuals (mean [SD] age, 59.7 [14.7] years; 263 228 [52.4%] women) were analyzed, of whom 351 897 had follow-up data for days 13 to 24. The cumulative incidence of SARS-CoV-2 infecti...Continue Reading

References

Feb 5, 2004·European Journal of Epidemiology·Gabriel ChodickEhud Kookia
Oct 15, 2020·The New England Journal of Medicine·Edward E WalshWilliam C Gruber
Dec 6, 2020·Nature Communications·Barak MizrahiEran Segal
Dec 11, 2020·The New England Journal of Medicine·Fernando P PolackUNKNOWN C4591001 Clinical Trial Group
Feb 25, 2021·The New England Journal of Medicine·Noa DaganRan D Balicer

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Citations

Jun 30, 2021·Nature Communications·Pinja JalkanenIlkka Julkunen
Jul 24, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Esther KisslingUNKNOWN I-MOVE-COVID-19 primary care study team (in addition to authors above)
Jul 13, 2021·JAMA : the Journal of the American Medical Association·Inbal GoldshteinYaakov Segal
Aug 14, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Khitam Muhsen, Dani Cohen
Sep 9, 2021·The New England Journal of Medicine·Anoop S V ShahDavid A McAllister
Sep 14, 2021·Annals of Internal Medicine·Seyed M MoghadasAlison P Galvani
Sep 28, 2021·Emerging Infectious Diseases·Aharona Glatman-FreedmanMichal Bromberg

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Software Mentioned

magrittr
survminer
tidyverse
ggplot2
R
R Project for Statistical Computing
dplyr
readtext
SPSS
survival

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