Assessment of endometrial sampling as a predictor of final surgical pathology in endometrial cancer

British Journal of Cancer
L HelpmanSharon Nofech-Mozes

Abstract

The histology and grade of endometrial cancer are important predictors of disease outcome and of the likelihood of nodal involvement. In most centres, however, surgical staging decisions are based on a preoperative biopsy. The objective of this study was to assess the concordance between the preoperative histology and that of the hysterectomy specimen in endometrial cancer. Patients treated for endometrial cancer during a 10-year period at a tertiary cancer centre were identified from a prospectively collected pathological database. All pathology reports were reviewed to confirm centralised reporting of the original sampling or biopsy specimens; patients whose biopsies were not reviewed by a dedicated gynaecological pathologist at the treating centre were excluded. Surgical pathology data including histology, grade, depth of myometrial invasion, cervical stromal involvement and lymphovascular space invasion (LVSI) as well as preoperative histology and grade were collected. Preoperative and final tumour cell type and grade were compared and the distribution of other high-risk features was analysed. A total of 1329 consecutive patients were identified; 653 patients had a centrally reviewed epithelial endometrial cancer on their o...Continue Reading

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Methods Mentioned

BETA
hysterectomy
biopsy
biopsies

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