Assessment of endothelial function by means of flow-mediated changes using pulse wave velocity

The Journal of Clinical Hypertension
Eduardo J RusakJorge Lerman

Abstract

Endothelial dysfunction is a leading cause of early development of cardiovascular diseases. Endothelial function can be assessed using ultrasound methods to watch the arterial flow-mediated dilation. It is also possible to find changes in pulse wave velocity (PWV) after induced ischemia related to the vessel diameter changes. Pre- and post-induced ischemia carotid-radial PWV was recorded in 226 hypertensive patients (150 women [63.5+/-12.4 years old] and 76 men [63.2+/-11.8 years old] and 55 healthy patients (38 women [63.1+/-12.6 years old] and 17 men [54.8+/-12.8 years old]). The authors considered normal endothelial function a PWV reduction of 5% from baseline. To assess nondependent endothelial dilation the authors performed carotid-radial PWV after sublingual administration of 5 mg of isosorbide dinitrate in a group of patients with abnormal flow-mediated dilation. A significant PWV reduction of 9.8% in normal patients and only 1.2% among hypertensive patients (P<.0005) was found. After sublingual isosorbide dinitrate intake the authors observed a greater fall in PWV (14%) than that observed in healthy people after induced ischemia. Carotid-radial PWV after induced ischemia decreased significantly in normal participants. N...Continue Reading

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Citations

Nov 25, 2014·Journal of the American Society of Hypertension : JASH·Yang LiuJason M Lazar
Jul 19, 2011·The Journal of Clinical Hypertension·John C MurphyAa Jennifer Adgey
May 4, 2013·Journal of Clinical Periodontology·Fábio VidalRicardo Guimarães Fischer

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