Assessment of endothelial function during the loading phase of infliximab in psoriasis: a potential predictor of its drug survival

International Journal of Dermatology
Momoko NakaoYoshihide Asano

Abstract

Tumor necrosis factor inhibitors decrease the risk of cardiovascular events in moderate to severe psoriasis, but the association between their effects on endothelial function and those on skin lesions has not been well studied. We investigated the association between infliximab effects on endothelial function during the loading phase and those on skin lesions in patients with psoriasis. We evaluated endothelial function with reactive hyperemia-peripheral arterial tonometry index (RHI) in 15 patients with psoriasis before the first and third infusions of infliximab. Patients were stratified into two groups; those who maintained Psoriasis Area and Severity Index (PASI) 75 response for more than 6 months (defined as responders) and the others (defined as nonresponders). Six weeks after the initiation of infliximab (before the third infusion), PASI scores were significantly improved compared with baseline, while RHI values were not altered in the whole patient group. However, when the responders and the nonresponders were analyzed separately, RHI values tended to be decreased before the third infusion compared with baseline in the nonresponders, while being unchanged in the responders. Importantly, the difference in ∆RHI reached a ...Continue Reading

References

Jan 14, 1999·The New England Journal of Medicine·R Ross
Jul 10, 2003·American Heart Journal·Jeffrey T KuvinJames E Udelson
Dec 8, 2004·Journal of the American College of Cardiology·Piero O BonettiAmir Lerman
Jul 7, 2005·The Journal of Experimental Medicine·Frank O NestleMichel Gilliet
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Joel M GelfandAndrea B Troxel
Aug 16, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·D D BalciE Egilmez
Nov 11, 2008·Clinical Reviews in Allergy & Immunology·Hasya ZingerYehuda Shoenfeld
Jun 17, 2009·Rheumatology International·Rifat Eralp UlusoyBekir Sitki Cebeci
Apr 17, 2010·Journal of the American College of Cardiology·Yasushi MatsuzawaHisao Ogawa
Sep 17, 2010·Internal and Emergency Medicine·Gianluigi MazzoccoliGianluigi Vendemiale
May 10, 2011·Circulation. Cardiovascular Imaging·Renate B SchnabelThomas Münzel
May 20, 2011·Nature·Peter LibbyGöran K Hansson
Aug 26, 2011·European Journal of Dermatology : EJD·Clara De SimoneAngelo Santoliquido
Mar 6, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·K Reich
Jun 8, 2012·Atherosclerosis·Giuseppe MurdacaFrancesco Puppo
Jul 4, 2012·Frontiers in Physiology·Yvonne Döring, Alma Zernecke
Aug 18, 2012·The British Journal of Dermatology·T Xu, Y-H Zhang
Oct 11, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·O AhlehoffP R Hansen
Feb 19, 2017·Journal of the American Academy of Dermatology·Junko TakeshitaJoel M Gelfand

❮ Previous
Next ❯

Citations

Dec 30, 2020·Dermatologic Therapy·Éva Anna PirosPéter Holló
Aug 26, 2021·Experimental Dermatology·Joanna WegnerEsther von Stebut

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.