Assessment of environmental contaminant-induced lymphocyte dysfunction

Environmental Health Perspectives
J B Silkworth, L D Loose

Abstract

Although it has been established that environmental contaminants can alter immune function, the mechanisms of action have yet to be determined. This paper reviews the effects of hydrocarbon environmental contaminants on lymphocyte function and presents an approach which may serve to delineate the mechanisms of action. The approach is based on the use of the developmental phases of an immune response and assays which can be used for their functional assessment. Possible interactions between environmental contaminants and lymphocyte function and factors which must be considered in the evaluation of immune status are discussed. In addition, a study on the influence of the chronic exposure to two polyhalogenated hydrocarbons, PCB and HCB, on several parameters of lymphocyte function in mice is presented.

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Citations

Jun 1, 1981·Environmental Health Perspectives·L D LooseF Blumenstock
Dec 1, 1995·Environmental Health Perspectives·H Tryphonas
Sep 30, 1999·Environmental Health Perspectives·C C MichielsenJ G Vos
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May 27, 2016·Toxicology and Industrial Health·Chinnu Sugavanam SenthilkumarNarayanan Ganesh
Aug 1, 1982·Toxicology and Applied Pharmacology·J B Silkworth, E M Grabstein
Mar 13, 2010·Journal of Biomedicine & Biotechnology·Jing LiuHubiao Chen
Nov 1, 1988·Toxicology and Applied Pharmacology·J A Hewett, R A Roth

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