Assessment of Epidemiological Trends in Craniosynostosis: Limitations of the Current Classification System

Plastic and Reconstructive Surgery. Global Open
Santiago R GonzalezMichael S Golinko

Abstract

Craniosynostosis affects 1 in 2,000 live births, which makes it one of the most common craniofacial abnormalities in the United States. Despite this fact, few national epidemiologic reports exist, although US and European studies have reported an increased incidence of metopic craniosynostosis. The aim of our study is to analyze the National Inpatient Sample (NIS) to support those conclusions. We identified hospitalizations from 1998 to 2012 by using the ICD-9-CM diagnosis code for congenital anomalies of skull and face bones (756.0) and procedure codes related to craniosynostosis repair (2.01, 2.03, 2.04, 2.06). We analyzed data from 37,815 hospitalizations and 49,505 reconstructive procedures. There was a 61.6% increase in the number of hospitalizations related to craniosynostosis repairs. There was a 180% increase in bone graft to skull procedures, 109% increase in other cranial osteoplasty, 54% increase in formation of cranial bone flap, and a 6% decrease in opening of cranial suture. We observed a steady rise in the number of craniosynostosis repairs performed, but whether this is a result of a true increase in incidence, better diagnosis, or change in treatment patterns needs further research. The current classification s...Continue Reading

References

Apr 25, 2003·Plastic and Reconstructive Surgery·Jayesh Panchal, Venus Uttchin
Mar 18, 2008·American Journal of Medical Genetics. Part a·Sheree L BouletMargaret A Honein
Jul 16, 2008·Plastic and Reconstructive Surgery·Jesse SelberScott P Bartlett
Mar 28, 2009·The Journal of Craniofacial Surgery·Jacques van der MeulenDominique Renier
Jul 3, 2009·Journal of Neurosurgery. Pediatrics·Federico Di RoccoDominique Renier
Oct 5, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·C F KweldamJ J N M van der Meulen
Sep 15, 2012·The Journal of Craniofacial Surgery·Hui Qing LeeAndrew L Greensmith
Oct 4, 2012·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Christine NguyenCatherine M Curtin
May 10, 2016·The Journal of Craniofacial Surgery·Katelyn G BennettChristian J Vercler
Jun 2, 2017·The Journal of Craniofacial Surgery·Oluwaseun A Adetayo
Jul 1, 2017·The Journal of Craniofacial Surgery·Ember L EwingsRobert D Wallace

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Citations

Apr 3, 2021·NeoReviews·Geoanna Bautista

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