Assessment of errors caused by X-ray scatter and use of contrast medium when using CT-based attenuation correction in PET.

European Journal of Nuclear Medicine and Molecular Imaging
Mohammad R Ay, Habib Zaidi

Abstract

Quantitative image reconstruction in positron emission tomography (PET) requires an accurate attenuation map of the object under study for the purpose of attenuation correction. Current dual-modality PET/CT systems offer significant advantages over stand-alone PET, including decreased overall scanning time and increased accuracy in lesion localisation and detectability. However, the contamination of CT data with scattered radiation and misclassification of contrast medium with high-density bone in CT-based attenuation correction (CTAC) are known to generate artefacts in the attenuation map and thus the resulting PET images. The purpose of this work was to quantitatively measure the impact of scattered radiation and contrast medium on the accuracy of CTAC. Our recently developed MCNP4C-based Monte Carlo X-ray CT simulator for modelling both fan- and cone-beam CT scanners and the Eidolon dedicated 3D PET Monte Carlo simulator were used to generate realigned PET/CT data sets. The impact of X-ray scattered radiation on the accuracy of CTAC was investigated through simulation of a uniform cylindrical water phantom for both a commercial fan-beam multi-slice and a prototype cone-beam flat panel detector-based CT scanner. The influence...Continue Reading

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Citations

Apr 18, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Alireza AhmadianHabib Zaidi
Aug 23, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Margit KleisBenjamin L Franc
Nov 3, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Thomas C KweeAbass Alavi
Mar 26, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Habib Zaidi, Issam El Naqa
Oct 21, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Pardis GhafarianHabib Zaidi
Apr 14, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mohammad R AyHabib Zaidi
Jun 20, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Parham GeramifarMohammad Reza Ay
Jul 6, 2007·Medical & Biological Engineering & Computing·Habib Zaidi, Mohammad Reza Ay
Apr 1, 2007·Biomedical Imaging and Intervention Journal·H Zaidi
Apr 1, 2007·PET Clinics·Habib Zaidi, Abass Alavi
Apr 1, 2007·PET Clinics·Habib ZaidiAbass Alavi
Apr 1, 2007·PET Clinics·Habib Zaidi, Marie-Louise Montandon
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Aug 2, 2008·Physics in Medicine and Biology·Catherine LemmensHabib Zaidi
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