Assessment of esophageal carcinoma undergoing concurrent chemoradiotherapy with quantitative dynamic contrast-enhanced magnetic resonance imaging

Oncology Letters
Jing LeiXiao Xu

Abstract

The aim of the present study was to investigate whether quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can predict an early response in primary esophageal carcinoma patients undergoing concurrent chemoradiotherapy. A total of 25 patients with who were pathologically confirmed stage II-III esophageal carcinoma underwent quantitative DCE-MRI prior to chemoradiotherapy, and at 3 weeks post-treatment, the quantitative parameters [K(trans) (volume transfer constant; the rate at which contrast agent distributes from the plasma to the EES), Kep (rate contrast; the rate at which the contrast agent that has diffused to the EES returns to the plasma) and Ve (the contrast agent percentage in the space of the extracellular fluid)] were analyzed respectively. The 25 cases were categorized as a complete response (CR) or a partial response (PR). An independent samples Mann-Whitney U test was used to compare the quantitative parameters between CR and PR. A receiver operating characteristic curve (ROC) was used to determine the best predictor. In total, 17 patients were in the CR group and 8 patients were in the PR group. Pretreatment Ktrans, Kep and Ve values were 0.54±0.17/min, 1.12±0.46/min and 0.37±0.14, respect...Continue Reading

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Citations

Jul 12, 2019·World Journal of Gastroenterology : WJG·Koichi HayanoHisahiro Matsubara
Apr 9, 2021·Frontiers in Oncology·Sangjune Laurence LeeStella Mook

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