PMID: 6975148Nov 1, 1981Paper

Assessment of exocrine pancreatic function by oral administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (Bentiromide): 5 years' clinical experience

The British Journal of Surgery
C LangD Gillessen

Abstract

Exocrine pancreatic function was assessed in 588 subjects by oral administration of 1 g of the chymotrypsin-labile peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid (Bentiromide) from 1974 to 1979. The pancreatic function test (PFT) was performed in 126 controls, 217 patients with pancreatic diseases, 196 patients with various non-pancreatic gastrointestinal disease, 18 patients with renal disease and 31 patients with various other diagnoses. In 62 of 72 patients (86 per cent) with chronic pancreatitis and in 19 of 25 (76 per cent) with pancreatic carcinoma, the excretion of p-aminobenzoic acid (PABA) in the urine was significantly less than in the controls. In contrast, 328 of 353 controls and patients with non-pancreatic diseases (93 per cent) had PABA excretion within normal limits. The sensitivity and specificity of the Bentiromide-test observed in this study is sufficient to detect moderate to severe disturbances of pancreatic exocrine function. The PFT has proved to be an easy and reliable screening test for pancreatic exocrine function in ambulatory as well as in hospitalized patients.

References

Aug 1, 1978·Archives of Disease in Childhood·M SacherD H Shmerling
Jan 1, 1979·Scandinavian Journal of Gastroenterology·C J MitchellJ Kelleher
Feb 16, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·W BornscheinM Otte
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Aug 1, 1950·The Journal of Clinical Investigation·W P DEISS, P P COHEN

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Citations

Oct 1, 1988·Digestive Diseases and Sciences·P G LankischB Lembcke
Oct 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·F J Hoek, G N Tytgat
May 1, 1984·Gut·C LangG A Stalder
May 1, 1996·Scandinavian Journal of Gastroenterology·B HeikiusS Lähde
Feb 1, 1983·Postgraduate Medical Journal·M OkadaT Omae
Mar 1, 1984·Pharmacotherapy·P P Toskes
Oct 15, 1985·Hospital Practice·P P Toskes
Jul 1, 1994·Annals of Clinical Biochemistry·N Lawson, I Chesner
Jan 1, 1988·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·Y BujanoverZ Spirer
Oct 4, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·L SinghJ D Wig

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