Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group

Journal of Surgical Oncology
Carol D MorrisRobert Lor Randall

Abstract

Complete surgical resection of primary tumors is critical for long-term control of high-grade osteosarcoma. Uniform assessment of the extent of surgical resection is important in clinical trials, though the accuracy of this reporting has been poorly studied. We conducted a retrospective cohort study of patients 5-40 years of age with newly diagnosed high-grade resectable osteosarcoma treated as part of the AOST0331 clinical trial at Children's Oncology Group institutions. The extent of surgical resection of the primary tumor was graded as wide or radical by the treating institution. Central assessment of the extent of resection by two orthopedic oncologists was compared with institutional assessment by reviewing pathology and operative reports. We included 956 patients who had data available for central review. The extent of resection reported by treating institutions was 536/956 (56%) radical and 420/956 (44%) wide. The extent of resection assessed by central review was 162/956 (17%) radical and 794/956 (83%) wide. The overall discordance rate for the cohort was 43%. Institutional reports of radical resection in high-grade osteosarcoma significantly over-estimate the proportion of patients undergoing radical resection. This hi...Continue Reading

References

Apr 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F GherlinzoniD Campanacci
Nov 14, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P PicciM Campanacci
Nov 22, 2001·Clinical Orthopaedics and Related Research·M SlugaR Kotz
Apr 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leo KagerUNKNOWN Cooperative Osteosarcoma Study Group

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Citations

Mar 15, 2020·Journal of Orthopaedic Surgery and Research·Wenjuan WangXiang Wang
Apr 17, 2019·Experimental and Therapeutic Medicine·Min XueBin Shan
Sep 4, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peter HohenbergerPaolo Casali

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