Assessment of Extrapulmonary Tuberculosis Using Gene Xpert MTB/RIF Assay and Fluorescent Microscopy and Its Risk Factors at Dessie Referral Hospital, Northeast Ethiopia

BioMed Research International
Yeshi MetaferiaDaniel Gebretsadik

Abstract

Tuberculosis is a major public health problem and extrapulmonary tuberculosis (EPTB) accounts for a significant proportion of tuberculosis cases worldwide. To determine the magnitude of EPTB, associated risk factors, and agreement of diagnostic techniques at Dessie Referral Hospital. A cross-sectional study was conducted on consecutive presumptive EPTB cases from March 1 to June 30, 2017. Sociodemographic characteristics and other variables were collected using a structured questionnaire. Clinical specimens were collected and processed using fluorescent microscopy and Gene Xpert assay. Data was analyzed using SPSS version 20. Chi-square test and logistic regression were done and a P value of ≤0.05 was taken as statistically significant. From a total of 353 presumptive EPTB cases the overall prevalence of Gene Xpert assay and smear confirmed patients was 8.8% and 2.5%, respectively. Tuberculosis lymphadenitis was the predominant (33.3%) type followed by pleural (11.9%) and peritoneal (6.7%) tuberculosis. Previous history of pulmonary tuberculosis was significantly associated with extrapulmonary infection (AOR:2.8; 95%CI: 1.05-7.54; p=0.04); however, other variables such as age, residence, sex, marital status, occupation, level o...Continue Reading

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Citations

Aug 28, 2020·The Cochrane Database of Systematic Reviews·Alexander W KayAnna M Mandalakas
Nov 10, 2020·Tropical Medicine & International Health : TM & IH·Adrian V HernandezJose E Vidal
Jan 16, 2021·The Cochrane Database of Systematic Reviews·Mikashmi KohliKaren R Steingart
Dec 7, 2020·Anais Brasileiros De Dermatologia·Lilian Lemos Costa, John Verrinder Veasey
May 11, 2021·Expert Review of Respiratory Medicine·Surendra K SharmaMikashmi Kohli
Jun 5, 2021·The American Journal of Dermatopathology·Debajyoti ChatterjeeV Ramesh

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Software Mentioned

GeneXpert®Dx System
LED
SPSS

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