Assessment of fertility among mustard-exposed residents of Sardasht, Iran: a historical cohort study

Reproductive Toxicology
Mostafa GhaneiDavid Haines

Abstract

Mustard gas (HD) is an alkylating agent with mutagenic and carcinogenic effects. Previous reports have demonstrated the ability of this class of compounds to cause adverse reproductive effects, however as of the time of this writing, few correlations have been established between HD exposure and human infertility. In the present study we hypothesize that infertility among mustard-exposed individuals is higher than among the general population. 117 couples, 90 with at least one partner, and 27 with both partners exposed to HD in June 1987, were evaluated for occurrence of infertility (defined as the failure to conceive after 12 months of unprotected intercourse). Two groups of subjects were considered in order to establish dose-responsive effect of HD on fertility. One cohort was married at the time of exposure and were evaluated in a time period 12 months from that date. The second cohort married after the date of exposure and each couple was evaluated for a year during a period following marriage. Measurements of these subjects were compared with worldwide incidence of fertility. A 7.5% rate of infertility was observed among couples who were married at the time of exposure; and a rate of 10.3% was noted among individuals singl...Continue Reading

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Jul 15, 1998·Human Reproduction·D S Irvine
Jul 11, 2001·Urology·M R Safarinejad
Nov 12, 2003·Journal of Occupational and Environmental Medicine·Shahriar KhateriDavid Haines

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Citations

Nov 19, 2009·Journal of Community Health·Mary FoxThomas Burke
Oct 9, 2015·Inhalation Toxicology·Eisa TahmasbpourYunes Panahi
Jan 30, 2010·Actas dermo-sifiliográficas·R Pita, S Vidal-Asensi
Dec 21, 2007·Reproductive Toxicology·Marcia C InhornAntoine B Hannoun
May 25, 2005·Fundamental & Clinical Pharmacology·Mahdi Balali-Mood, Mehrdad Hefazi
Jul 6, 2012·Basic & Clinical Pharmacology & Toxicology·Emadodin Darchini-MaraghehMahdi Balali-Mood
Jun 29, 2017·Journal of Cellular Biochemistry·Yunes PanahiAmirhossein Sahebkar
Jan 24, 2008·The Annals of Pharmacotherapy·Matthew J Geraci
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May 1, 2020·Archives of Iranian Medicine·Ayeh Bolouki, Fatemeh Zal
Dec 5, 2018·Toxicology Research·Asghar Beigi HarcheganiAlireza Shahriary

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