Assessment of fetal and placental blood flow in primates using contrast enhanced ultrasonography

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
U P SchmiedlR Schlief

Abstract

Ultrasonographic contrast agents that stay within the vascular space and do not cross the placenta may permit differentiation between the maternal and fetal portions of the placenta and may be clinically useful for diagnosis of placental abnormalities. This study was performed to assess the effects of Levovist (Schering AG, Berlin) on the placental circulation and to determine whether hemodynamic effects on the fetus occur. Ten studies were performed in five pregnant macaques (median weight, 9.15 kg; range, 6.15 to 11 kg; median gestational age, 121 days; range, 34 days to term) under anesthesia. Gray scale, color, and duplex Doppler sonographic scans of the fetus and placenta were acquired using a 5 MHz curved array transducer. Fetal heart rate, resistive index, and systolic-diastolic ratios were measured in the fetal middle cerebral artery, aorta, umbilical artery, and uterine artery before and after administration of contrast agent. The following dose regimen was tested: 5 ml of physiologic saline solution followed by 0.1 ml/kg of 300 mg/ml Levovist (diagnostic dose), 0.5 ml/kg of 400 mg/ml Levovist (maximum dose), and 5 ml physiologic saline solution. The order of diagnostic dose and maximal dose was randomized among animal...Continue Reading

Citations

Nov 16, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·E MourierP Chavatte-Palmer
Sep 5, 2020·BioTechniques·Victoria Hj Roberts, Antonio E Frias
Mar 24, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jacques S Abramowicz
Apr 20, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A W WelshN M Fisk
Dec 17, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·Y SongK Shen
Nov 16, 2013·Journal of Diagnostic Medical Sonography : JDMS·Kevin D EvansCarolyn M Sommerich
Jul 31, 2021·Placenta·Vijayalakshmi SrinivasanAlys R Clark

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