PMID: 9451563Feb 6, 1998Paper

Assessment of fine-needle aspiration sampling technique in thyroid nodules

Diagnostic Cytopathology
Y M MusgraveK B Ain

Abstract

A prospective two-yr study was undertaken to assess the heterogeneity of thyroid nodules using the fine-needle aspiration (FNA) technique of systematic regional sampling. In addition, we determined the number of regions to be sampled to minimize non-diagnostic results, and to optimally characterize thyroid nodules. FNA was performed on 74 nodules > or = 1.5 cm. in diameter in five distinct regions in sequence (center, then four quadrants starting at 12:00, clockwise). Slides from each region were coded, randomized, subjected to blind review, and categorized as non-diagnostic (ND), benign (B), indeterminate (ID), suspicious/neoplastic (S/N), or malignant (M). Final cytologic diagnosis (CD) was made from all slides of each nodule. The ND rate for center FNAs alone was 16%, but addition of the 12:00 region decreased it to 5.3%. With 3, 4, or 5 sequential sites the nondiagnostic rates were 4, 2.6, and 2.6%. The center region diagnosis was identical to the final CD in 71% of the cases. Addition of the 12:00 region increased the concordance to 88%. Three sequential regions equaled the CD in 93% of cases, and 4 regions equaled the CD in 99% of cases. All nodules characterized as M or S/N were resected as were 76% of the ID nodules. Of...Continue Reading

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Citations

Nov 13, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Min Jung KimSung Hee Park
Sep 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Ji-Young ParkSeong Hun Kim
Aug 8, 2012·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Cyrille NaïmDonald Eddé
Aug 15, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J I Mechanick, A Carpi
Aug 31, 2000·Cancer·D N PollerM Perry
Feb 4, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Lamia FathallahMousa A Al-Abbadi
Mar 9, 2005·Diagnostic Cytopathology·Mojghan AmrikachiIbrahim Ramzy
Mar 12, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Israel B OrijaS Sethu K Reddy
Aug 18, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Zubair W Baloch, Virginia A LiVolsi
Jan 16, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Israel B OrijaAmir H Hamrahian

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