PMID: 9176533May 1, 1997Paper

Assessment of fitness in patients with cystic fibrosis and mild lung disease

Thorax
P McLoughlinM X FitzGerald

Abstract

Maximal exercise testing is used in patients with cystic fibrosis to assess functional status and prognosis. The lactate threshold is an index of aerobic fitness with significant advantages over maximal exercise tests. This study was undertaken to determine if the lactate threshold might be identified, non-invasively, in adult patients with cystic fibrosis and mild lung disease by measurement of ventilatory and gas exchange parameters. Ten subjects with mild cystic fibrosis (forced vital capacity (FVC) > 70% predicted) and 10 healthy controls undertook an incremental exercise test on a bicycle ergometer. Ventilation and gas exchange parameters were measured continually and arterialised venous blood pH, carbon dioxide tension (PCO2), and lactate concentrations were measured at intervals throughout the tests. In subjects with cystic fibrosis there was no significant difference between the mean gas exchange and lactate thresholds (mean difference 1.0 (95% confidence interval (CI) of the mean -1.5 to 3.44) ml/kg/min). In contrast, there was a significant difference between the mean ventilatory and lactate thresholds (3.8 (95% CI 0.9 to 6.7) ml/kg/min). Arterialised venous PCO2 increased significantly during the exercise tests. In h...Continue Reading

References

Sep 1, 1979·European Journal of Applied Physiology and Occupational Physiology·W KindermannJ Keul
Jan 1, 1979·Medicine and Science in Sports·P A FarrellD L Costill
Jan 1, 1992·Annals of Epidemiology·T A ManolioW R Harlan
Sep 1, 1992·Journal of Applied Physiology·P McLoughlinD M Band
Dec 17, 1992·The New England Journal of Medicine·P A NixonC F Doershuk
Oct 1, 1992·International Journal of Sports Medicine·L H NortonK I Norton
Jan 1, 1991·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·H G HeijermanJ H Dijkman
Feb 1, 1988·International Journal of Sports Medicine·J K Stanghelle
Jan 1, 1986·American Journal of Diseases of Children·L D EdlundT D Adams
Dec 1, 1985·Journal of Applied Physiology·W L BeaverB J Whipp
Apr 1, 1971·Archives of Disease in Childhood·S Godfrey, M Mearns
Feb 1, 1984·The American Review of Respiratory Disease·K Wasserman
May 1, 1984·The American Review of Respiratory Disease·K G Henke, D M Orenstein
Jan 1, 1982·European Journal of Applied Physiology and Occupational Physiology·S KumagaiK Asano
Feb 12, 1994·BMJ : British Medical Journal·A K Webb, T J David

❮ Previous
Next ❯

Citations

Nov 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Daniel StevensCraig A Williams
Jun 25, 1998·Disability and Rehabilitation·A J MoorcroftA K Webb
Nov 21, 2008·Revue de pneumologie clinique·C KarilaA Denjean
May 28, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·D StevensE Tullis
Sep 20, 2005·Respiratory Physiology & Neurobiology·Jonathan D DoddCharles G Gallagher
Sep 16, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alex Horsley, Salman Siddiqui
Jul 7, 2007·Physiological Reviews·Toshinori Yoshida, Rubin M Tuder
Oct 3, 2015·Journal of Applied Physiology·Bradley S QuonJordan A Guenette

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.