Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Tormod A M EgelandE K Rofstad

Abstract

A noninvasive method for assessment of the extent of hypoxia in experimental and human tumors is highly needed. In this study, the potential usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was investigated, using gadopentetate dimeglumine (Gd-DTPA) as contrast agent and A-07 human melanoma xenografts as tumor model. DCE-MRI was performed at a voxel size of 0.3 x 0.6 x 2.0 mm3 with spoiled gradient-recalled sequences. Images of E . F (E is the initial extraction fraction of Gd-DTPA and F is perfusion) and lambda (the partition coefficient of Gd-DTPA, which is proportional to extracellular volume fraction) were obtained by Kety analysis of DCE-MRI data. The study was based on the hypothesis that hypoxic tissue would have low E . F (i.e., poor oxygen supply) and/or low lambda (i.e., high cell density and, hence, high oxygen consumption rate). Twenty-two tumors were first subjected to DCE-MRI and then to measurement of fraction of hypoxic cells, using a radiobiological assay. E . F was found to be strongly correlated to fraction of hypoxic cells (P < 0.000001), whereas significant correlation between lambda and fraction of hypoxic cells could not be detected. It is thus possible that E . F may be a usef...Continue Reading

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Citations

Aug 6, 2011·International Journal of Radiation Oncology, Biology, Physics·Kirsti Marie ØvrebøEinar K Rofstad
Oct 12, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kristine GulliksrudEinar K Rofstad
Jul 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine EllingsenEinar K Rofstad
Feb 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Christine EllingsenEinar K Rofstad
Nov 1, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kristine GulliksrudEinar K Rofstad
Jun 11, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tormod A M EgelandEinar K Rofstad
Jun 27, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Inna V LinnikGeoff J M Parker
Dec 27, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kirsti Marie ØvrebøEinar K Rofstad
Aug 16, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kristine GulliksrudEinar K Rofstad
Jan 26, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kristine GulliksrudEinar K Rofstad
Apr 15, 2016·PloS One·Qi QiSlav Yartsev
Jul 21, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·SoHyun HanEllen Ackerstaff
Dec 1, 2018·International Journal of Radiation Biology·William CroweDawen Zhao
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Oct 3, 2018·The British Journal of Radiology·James P B O'ConnorJohn C Waterton
Jul 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Jon-Vidar GaustadEinar K Rofstad
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kjetil G BrurbergEinar K Rofstad
Sep 29, 2011·Journal of Radiation Research·Hiroshi Harada

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