Abstract
The aim of the present study was to assess the frequency dependency of the effects of almokalant, a selective class III antiarrhythmic drug, on ventricular repolarization using recordings of monophasic action potentials and measurements of ventricular paced QT intervals. Twenty male volunteers were studied during almokalant infusion aiming at plasma concentrations (Cpl) of 20, 50, 100, and 150 nmol/l. The duration of monophasic action potential at 90% repolarization (MAPD) was measured during incremental and premature ventricular extrastimulation. The ventricular paced QT interval was measured during incremental stimulation from the apical region (RV APEX) and the outflow tract (RVOT) of the right ventricle, and the frequency dependence was analyzed using a linear regression model. At an almokalant dose of Cpl > or = 50, there was a significant prolongation of the MAPD of 10-15%. The prolongation was of equal magnitude at all paced cycle lengths (CL). The MAPD of ventricular extrasystole increased in parallel over the range of coupling intervals studied and was significantly prolonged at Cpl 100 and 150. The ratio between the MAPD of the extrasystoles and preceding beats was unaltered after almokalant infusion. The ventricular ...Continue Reading
References
Sep 1, 1992·Journal of Cardiovascular Pharmacology·G DukerL Carlsson
Nov 1, 1992·Cardiovascular Research·E WettwerU Ravens
May 1, 1992·Journal of the American College of Cardiology·J M MorganE Rowland
Oct 15, 1992·The American Journal of Cardiology·A C WiesfeldK I Lie
Dec 1, 1991·Journal of Cardiovascular Pharmacology·L CarlssonG Duker
Jan 1, 1992·British Heart Journal·J M MorganE Rowland
Nov 1, 1991·The American Journal of Cardiology·C SchmittW Kübler
Feb 1, 1990·Circulation·L M Hondeghem, D J Snyders
Jul 1, 1990·The Journal of General Physiology·M C Sanguinetti, N K Jurkiewicz
Mar 1, 1990·Circulation·K NademaneeC M Pruitt
Nov 1, 1985·European Heart Journal·N Edvardsson, S B Olsson
May 1, 1982·Pacing and Clinical Electrophysiology : PACE·J R MilneA J Camm
Nov 1, 1981·American Heart Journal·S B Olsson, N Edvardsson
Aug 1, 1995·Journal of Cardiovascular Pharmacology·B Darpö, N Edvardsson
May 1, 1995·Journal of Cardiovascular Pharmacology·B DarpöN Edvardsson
Jun 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·A OhlerU Ravens
Apr 1, 1994·European Heart Journal·S YuanC Blomström-Lundqvist
Jan 1, 1994·Current Opinion in Cardiology·B N Singh, R Ahmed
Aug 1, 1993·Cardiovascular Drugs and Therapy·E Carmeliet
Dec 1, 1993·Cardiovascular Research·L CarlssonG Schiller-Linhardt
May 1, 1993·Cardiovascular Research·C AbrahamssonL Carlsson
Nov 1, 1993·Circulation Research·E Carmeliet
Jan 1, 1993·Circulation Research·N K Jurkiewicz, M C Sanguinetti
Oct 1, 1995·Journal of Cardiovascular Pharmacology·B DarpöN Edvardsson
Citations
Jan 21, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Nenad SarapaArthur J Moss
Apr 16, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Nkechi E AzieJoseph C Fleishaker