Assessment of functional and behavioral changes sensitive to painful disc degeneration

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Alon LaiJames C Iatridis

Abstract

The development of an in vivo rodent discogenic pain model can provide insight into mechanisms for painful disc degeneration. Painful disc degeneration in rodents can be inferred by examining responses to external stimuli, observing pain-related behaviors, and measuring functional performance. This study compared the sensitivity of multiple pain and functional assessment methods to disc disruption for identifying the parameters sensitive to painful disc degeneration in rats. Disc degeneration was induced in rats by annular injury with saline injection. The severity of disc degeneration, pain sensitivity, and functional performance were compared to sham and naïve control rats. Saline injection induced disc degeneration with decreased disc height and MRI signal intensity as well as more fibrous nucleus pulposus, disorganized annular lamellae and decreased proteoglycan. Rats also demonstrated increased painful behaviors including decreased hindpaw mechanical and thermal sensitivities, increased grooming, and altered gait patterns with hindpaw mechanical hyperalgesia and duration of grooming tests being most sensitive. This is the first study to compare sensitivities of different pain assessment methods in an in vivo rat model of d...Continue Reading

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Citations

Nov 28, 2015·The Spine Journal : Official Journal of the North American Spine Society·Alon LaiJames C Iatridis
Sep 13, 2016·Genes & Diseases·Yi FengJinxi Wang
Nov 19, 2017·Journal of Cellular Physiology·Changgui ShiHee-Jeong Im
Aug 11, 2017·Annals of the New York Academy of Sciences·Grace E MosleyJames C Iatridis
Sep 19, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Changgui ShiHee-Jeong Im
Jan 4, 2019·Annals of the New York Academy of Sciences·Olivia M TorreJames C Iatridis
Dec 10, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Seunghwan LeeLaura S Stone
Jul 3, 2020·JOR Spine·Juliane D GlaeserDmitriy Sheyn
Nov 7, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yucheng JiaoPeng Cao
Jun 27, 2020·Frontiers in Bioengineering and Biotechnology·Zhen LiGernot Lang
Jul 4, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Haowen CuiZhaomin Zheng
Nov 12, 2020·Experimental Biology and Medicine·Demissew Shenegelegn MernClaudius Thomé
Jun 13, 2021·The Spine Journal : Official Journal of the North American Spine Society·Hye Rim SuhHee Chul Han

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