Assessment of genotoxicity in rats treated with the antidiabetic agent, pioglitazone

Environmental and Molecular Mutagenesis
Abdulkerim BedirMuhlise Alvur

Abstract

Pioglitazone (PIO), a member of the thiazolidinedione class of antidiabetic agents, specifically targets insulin resistance. Drugs of this class act as ligands for the gamma subtype of the peroxisome proliferator-activated receptor. Although troglitazone, another drug in this class, displayed unacceptable hepatotoxicity, PIO was approved for human use by the U.S. Food and Drug Administration. To our knowledge, there are no published reports on the genotoxicity of PIO; however, the package insert indicates that it has minimal genotoxicity. In this study, we used the comet assay to investigate the DNA damage in the peripheral blood and liver cells of rats treated with PIO. Sixteen male Sprague-Dawley rats were randomly distributed into four groups, and dosed daily for 14 days by oral gavage with 0, 10, 20, and 40 mg/kg/day PIO. A dose-dependent increase in DNA damage, as assessed by % tail DNA, was observed in both hepatocytes and blood lymphocytes of the PIO-treated groups, with significant increases detected between the rats treated with all the doses of PIO and the control, and between the rats treated with different PIO doses (P < 0.005 to P < 0.0001). Treating nuclei from the exposed animals with an enzyme cocktail containin...Continue Reading

References

Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Feb 17, 1996·Lancet·P DandonaT Nicotera
Jul 1, 1997·Drugs·C M Spencer, A Markham
Mar 28, 1998·The New England Journal of Medicine·P B Watkins, R W Whitcomb
Jul 29, 1998·Free Radical Biology & Medicine·A R CollinsM Dusinská
May 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·C Day
May 20, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A R Collins
Jul 10, 1999·Drugs·J A Balfour, G L Plosker
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Sep 13, 2000·Drugs·P S Gillies, C J Dunn
Dec 6, 2000·The Journal of Clinical Investigation·C R KahnS E Cohen
Mar 10, 2001·Recent Progress in Hormone Research·P Froguel, G Velho
May 26, 2001·The Journal of Endocrinology·P DeleriveB Staels
Aug 21, 2001·Annals of Internal Medicine·K Maeda
Mar 20, 2002·Annals of Internal Medicine·Louis D MayDavid E Rubin
May 16, 2002·Journal of Cellular Physiology·Satoru KawakamiKazunori Kihara
Dec 11, 2002·Mutagenesis·A HartmannUNKNOWN 4th International Comet Assay Workshop
Dec 31, 2002·Mutation Research·Krzysztof KońcaAndrzej Wojcik
Feb 22, 2003·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Padma Kumar NarayananPeter Bugelski
Jul 3, 2004·The Lancet Oncology·Christian GrommesMichael T Heneka
Jul 22, 2004·The Annals of Pharmacotherapy·Todd R MarcySteve M Blevins
Aug 1, 1997·Expert Opinion on Investigational Drugs·S L Grossman, J Lessem
Apr 21, 2006·Basic & Clinical Pharmacology & Toxicology·Peter Møller
Nov 2, 2006·Environmental and Molecular Mutagenesis·Abdulkerim BedirMuhlise Alvur

❮ Previous
Next ❯

Citations

Jul 14, 2012·Mutation Research·Karem AlzoubiNizar Mhaidat
Sep 28, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Noor Ahmad ShaikDurga Koteswara Rao
Jun 6, 2009·Chemico-biological Interactions·S M AttiaA A Alhaider
Sep 10, 2013·Endocrinology and Metabolism Clinics of North America·Efrat KravitzMichal Schnaider Beeri
Aug 21, 2010·Critical Reviews in Toxicology·S J Enoch, M T D Cronin
Jan 1, 2008·Clinical Medicine. Oncology·Syed Imam RabbaniSalma Khanam
Jan 27, 2021·Environmental and Molecular Mutagenesis·Zülal Atlı ŞekeroğluLouis S Liou
Apr 6, 2020·Toxicology Letters·Andrew CollinsAmaya Azqueta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Environmental and Molecular Mutagenesis
Abdulkerim BedirMuhlise Alvur
Diabetic Medicine : a Journal of the British Diabetic Association
C Day
Mutation Research
Janusz BlasiakJozef Drzewoski
© 2021 Meta ULC. All rights reserved