PMID: 11917717Mar 29, 2002Paper

Assessment of gliadin in pharmaceutical products - important information to the orientation of celiac disease patients

Arquivos De Gastroenterologia
V L SdepanianU Fagundes-Neto

Abstract

Some drugs might contain gliadin which can be dangerous for celiac disease patients. Detect gliadin in pharmaceutical products commonly used in Brazil. We analyzed 78 pharmaceutical products selected aleatory from a list of 180 products most frequently sold at Brazilian community pharmacies. The analyzed samples were analgesics (n = 9), anthelmintics (n = 3), antacids (n = 8), antibiotics (n = 13), anticholesteremics (n = 1), anticonvulsants (n = 2), antidepressants (n = 2), antiemetics (n = 3), antihypertensives (n = 3), antihistaminics (n = 3), anti-inflammatories (n = 7), antipyretics (n = 2), bronchodilators (n = 1), laxatives (n = 1), oral contraceptives (n = 5) and vitamins (n = 10). The samples were analyzed by enzyme immunoassay based on monoclonal antibodies omega-gliadins, the elected technique according to the Codex Alimentarius Commission WHO/FAO. All samples were analyzed in duplicate. The sensitivity of this test is 4 mg of gliadin/100 g of product. Only one (1.3%) out of 78 pharmaceutical products contained detectable amounts of gliadin (5.5 mg/100 g). The active ingredient of this drug is ranitidine. According to the Codex Alimentarius Commission WHO/FAO the intake of 10 mg of gliadin/day should not be exceeded ...Continue Reading

References

Jul 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·I D MileticS S Schiffman
Jun 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·I Stankovic, I Ofenbeher-Miletic
Jul 7, 2000·Arquivos De Gastroenterologia·V L SdepanianU Fagundes Neto

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