Assessment of health-related quality of life in kidney transplant patients receiving tacrolimus (FK506)-based versus cyclosporine-based immunosuppression. FK506 Kidney Transplant Study Group

Transplantation
C F ShieldT F Goss

Abstract

We evaluated health-related quality of life (HQL) in kidney transplant patients participating in a multicenter, prospective, randomized, phase III trial comparing tacrolimus to cyclosporine. HQL data were available for 303 of 412 patients and assessed with the SF-36 Health Survey and six multi-item scales: Current Health, Health Outlook, Health Distress, Fleming Self-Esteem, Bergner Physical Appearance, and Sexual Functioning. Patients completed surveys at baseline, week 6, and months 3, 6, and 12. The mean change in HQL was evaluated by rejection occurrence and number of hospitalizations. Analysis of covariance was used to model endpoint HQL scores as a function of treatment group and baseline HQL. All scales but two met psychometric standards for group-level comparisons. Baseline demographics and HQL scores were not different by treatment. The mean HQL change was lower for patients with rejection compared with no rejection in seven of eight SF-36 scales and three of four remaining supplemental scales. One year after transplantation, study patients were functioning at least as well as half of the general population in Vitality and Role-Emotional Functioning, moving from the 18th percentile of the U.S. population scores to the ...Continue Reading

References

Aug 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K B MeyerA R Davies
Jan 1, 1993·Transplantation·D J KileyR Pollak
May 1, 1996·Journal of the American Society of Nephrology : JASN·K M BeusterienJ E Ware

❮ Previous
Next ❯

Citations

Mar 24, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·K-H Schulz, F Thaiss
Mar 26, 2004·Transplantation Proceedings·P A Keown
Dec 20, 2000·Transplantation Proceedings·Y IchikawaS Nagano
Mar 27, 2001·Transplantation Proceedings·S NakataY Tano
Mar 27, 2001·Transplantation Proceedings·J ReimerU Heemann
Sep 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·John T JosephRahul M Jindal
Feb 24, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A M Rosario, J B Young
Dec 24, 2005·Transplantation·Leila TricotEric Thervet
Dec 20, 2007·Transplantation·Teresa OrtegaUNKNOWN Research Network on Transplantation
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·N von SteinbüchelD Carr
Mar 18, 2005·Seminars in Dialysis·Rebecca J Muehrer, Bryan N Becker
May 29, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Soha NamaziIman Karimzadeh
Aug 9, 2001·Journal of Clinical Periodontology·J A JamesC D Short
Mar 25, 2004·Clinical and Experimental Hypertension : CHE·Yasuko OkanoSatoshi Umemura
Mar 15, 2011·European Journal of Medicinal Chemistry·Xiaodong PangXinyi Zhang
Jan 3, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin HowellKirsten Howard
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F ValderrábanoJ M López-Gómez
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E HricikR M Ferguson
Jan 22, 2005·Clinical Transplantation·Jaroslav RosenbergerJohan W Groothof F
Mar 3, 2005·Clinical Transplantation·Suji LeeDaniel G Glicklich
Aug 27, 2005·The British Journal of Dermatology·F J MoloneyG M Murphy
May 25, 2005·Pediatric Transplantation·Kiran K DhanireddyAllan D Kirk
Mar 31, 2004·Pediatric Transplantation·Debbie S Gipson, Maria E Ferris
May 17, 2008·Clinical Transplantation·Zeeshan ButtDavid Cella
Sep 15, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Graeme RussDennis A Revicki
Jul 18, 2006·Clinical Transplantation·Maristela BohlkeMaria Claudia Irigoyen
Apr 17, 2007·Journal of Clinical Periodontology·Ricardo Takiy SekiguchiRoberto Fraga Moreira Lotufo
Nov 28, 2009·Journal of Advanced Nursing·Hongxia LiuC Wright Pinson
Sep 26, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Indraneel BhattacharyyaDonald M Cohen
Feb 21, 2003·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Bonnie SiegalM J McGuire
Sep 29, 2004·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Irina CleemputSabina De Geest
Sep 25, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Ylian S LiemM G Myriam Hunink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.