Assessment of hemostatic profile in patients with mild to advanced liver cirrhosis.

World Journal of Gastroenterology : WJG
Elisabeth Hannah AdamNina Weiler

Abstract

Hemostasis of patients suffering from liver cirrhosis is challenging due to both, pro- and anticoagulatory disorders leading to hemostatic alterations with distinct abnormalities of coagulation. Pathological changes in conventional coagulation analysis and platelet count are common manifestations of decreased liver synthesis of coagulation factors and reduced platelet count in these patients. However, conventional coagulation analysis and platelet count do not reflect in-vivo coagulation status or platelet function. The purpose of this present observational study was therefore to assess the haemostatic profile including plasmatic coagulation using thrombelastometry and impedance aggregometry for platelet function in patients suffering from liver cirrhosis. To assess the hemostatic profile of cirrhotic patients according to model for end-stage liver disease (MELD) score. Our study included both in- and outpatients suffering from liver cirrhosis attending the out- and inpatient care of the department of hepatology. Demographic and biochemical data as well as medical history including cause of liver cirrhosis, end stage kidney failure and medication with anticoagulants were recorded. To assess the hemostatic profile, platelet func...Continue Reading

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Methods Mentioned

BETA
flow cytometry
blood draw

Clinical Trials Mentioned

NCT04265508

Software Mentioned

INTEM
SPSS
EXTEM
GraphPad Prism
FIBTEM

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