Assessment of heterogeneity in an individual participant data meta-analysis of prediction models: An overview and illustration

Statistics in Medicine
Ewout W SteyerbergHans C van Houwelingen

Abstract

Clinical prediction models aim to provide estimates of absolute risk for a diagnostic or prognostic endpoint. Such models may be derived from data from various studies in the context of a meta-analysis. We describe and propose approaches for assessing heterogeneity in predictor effects and predictions arising from models based on data from different sources. These methods are illustrated in a case study with patients suffering from traumatic brain injury, where we aim to predict 6-month mortality based on individual patient data using meta-analytic techniques (15 studies, n = 11 022 patients). The insights into various aspects of heterogeneity are important to develop better models and understand problems with the transportability of absolute risk predictions.

References

Aug 1, 1991·Statistics in Medicine·M E MillerW M Tierney
Nov 1, 1990·Statistics in Medicine·J C Van Houwelingen, S Le Cessie
Mar 13, 1999·Annals of Internal Medicine·A C JusticeJ A Berlin
Jul 27, 2001·Journal of Clinical Epidemiology·E W SteyerbergJ D Habbema
Aug 3, 2004·Statistics in Medicine·Ewout W SteyerbergJ Dik F Habbema
Sep 15, 2005·Statistics in Medicine·Aris PerperoglouHans C van Houwelingen
Feb 8, 2006·Annals of Internal Medicine·Brendan M Reilly, Arthur T Evans
Dec 13, 2006·The Journal of Urology·E W SteyerbergF H Schröder
Mar 23, 2007·Journal of Neurotrauma·Gordon D MurrayEwout W Steyerberg
Sep 3, 2010·American Journal of Epidemiology·Yvonne VergouweEwout W Steyerberg
Jun 3, 2011·The New England Journal of Medicine·Jonathan F FinksJohn D Birkmeyer
May 26, 2012·PLoS Medicine·Walter BouwmeesterKarel G M Moons
Aug 14, 2012·BMC Medical Research Methodology·Thomas P A DebrayKarel G M Moons
Oct 5, 2012·The New England Journal of Medicine·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Feb 9, 2013·PLoS Medicine·Ewout W SteyerbergUNKNOWN PROGRESS Group
Apr 16, 2013·PloS One·Thomas P A DebrayRichard David Riley
Jul 17, 2013·Statistics in Medicine·Matthieu Resche-RigonUNKNOWN PROG-IMT Study Group
Jan 9, 2014·BMC Medical Research Methodology·Ikhlaaq AhmedRichard D Riley
Mar 19, 2014·Statistics in Medicine·Elisa ShengAshlee Duncan
Apr 23, 2014·Statistics in Medicine·Thomas P A DebrayKarel G M Moons
Sep 3, 2014·Journal of Clinical Epidemiology·Thomas P A DebrayKarel G M Moons
Feb 15, 2015·Biostatistics·Hein Putter, Hans C van Houwelingen
May 20, 2015·Journal of Clinical Epidemiology·Ewout W Steyerberg, Frank E Harrell
Oct 16, 2015·PLoS Medicine·Thomas P A DebrayUNKNOWN Cochrane IPD Meta-analysis Methods group
Jan 17, 2016·Journal of Clinical Epidemiology·Ben Van CalsterEwout W Steyerberg
Jun 6, 2016·Journal of Clinical Epidemiology·Peter C AustinEwout W Steyerberg
Jul 28, 2016·Statistical Methods in Medical Research·Ting-Li SuMatthew Sperrin
Sep 21, 2016·Statistical Methods in Medical Research·Matthieu Resche-Rigon, Ian R White
Sep 21, 2016·Statistical Methods in Medical Research·L WynantsB Van Calster
Nov 29, 2016·Statistics in Medicine·Yvonne VergouweEwout W Steyerberg
May 26, 2017·Statistics in Medicine·Peter C Austin, Juan Merlo
Jul 12, 2017·Statistics in Medicine·Deborah Kunkel, Eloise E Kaizar

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Citations

Feb 28, 2020·Journal of the American Medical Informatics Association : JAMIA·Yingxiang HuangLucila Ohno-Machado
Apr 23, 2020·Journal of Neurotrauma·Isabel R A Retel HelmrichEwout W Steyerberg
Jul 25, 2019·Diagnostic and Prognostic Research·Thomas P A DebrayRichard D Riley
Jan 21, 2021·Journal of Neurotrauma·Benjamin Yaël GravesteijnUNKNOWN CENTER-TBI Collaborators
Feb 4, 2021·Diabetes Care·Anastassios G Pittas, Ethan M Balk
May 6, 2021·Statistics in Medicine·Valentijn M T de JongThomas P A Debray
May 28, 2021·Interactive Cardiovascular and Thoracic Surgery·Shubhra SinhaUmberto Benedetto
May 22, 2021·International Journal of Medical Informatics·Anne De HondBas De Groot

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