Assessment of high-sensitivity C-reactive protein tests for the diagnosis of hepatocellular carcinoma in patients with hepatitis B-associated liver cirrhosis

Oncology Letters
Lina MaYan Xie

Abstract

Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide, with high morbidity and mortality. Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma and the majority (~80%) of hepatocellular carcinoma patients in China exhibit co-morbidity with HBV-associated liver cirrhosis. The goal of reliable early diagnostic and prognostic techniques for HBV-associated HCC remains unrealized. The aim of the present study was to explore the efficacy of serum high-sensitivity C-reactive protein (hs-CRP) tests in the early diagnosis of HCC in patients with HBV-associated liver cirrhosis. A cohort of 493 patients with HBV-associated liver disease was divided into three groups: Chronic HBV (CHB) group; liver cirrhosis without HCC (LC) group; and liver cirrhosis with HCC (HCC) group. A further 47 healthy individuals comprised the healthy control (CN) group. Comparative analyses of clinical symptoms, histopathology, ultrasound imagery, computed tomography, magnetic resonance imaging, biochemistry [α-fetoprotein (AFP) and liver function enzymes], and hs-CRP tests were conducted across these four groups. Immunohistochemical analysis showed that CRP is strongly expressed in HC...Continue Reading

References

May 29, 2000·Journal of Gastroenterology and Hepatology·Z Y LinW Y Chang
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jan 31, 2002·World Journal of Gastroenterology : WJG·Z Y Tang
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lukas A HeflerAlexander Reinthaller
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Aug 14, 2009·Expert Review of Gastroenterology & Hepatology·Mohamed I F ShariffSimon D Taylor-Robinson
May 1, 2008·Expert Review of Clinical Immunology·Andres PeisajovichTerry W Du Clos
May 27, 2010·Respiratory Research·Francisco Garcia-RioUNKNOWN EPI-SCAN Steering Committee
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S JelicUNKNOWN ESMO Guidelines Working Group
Nov 30, 2010·Recent Patents on Anti-cancer Drug Discovery·Chuanrui XuXin Chen
Dec 1, 2010·Journal of Evaluation in Clinical Practice·Madhvi PatelSimon D Taylor-Robinson
Jan 5, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alfredo Alberti, Nicola Caporaso
Feb 26, 2011·Omics : a Journal of Integrative Biology·John M Luk, Angela M Liu
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
Jun 22, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Maria AttaAjax Atta
Jun 23, 2012·Digestive Diseases·Gyongyi Szabo, Dora Lippai
Sep 11, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wolfgang SieghartMarkus Peck-Radosavljevic
Oct 26, 2012·Journal of Gastroenterology and Hepatology·Chih-Lin Lin, Jia-Horng Kao
Dec 21, 2012·Medical Oncology·Ming XuJinping Zhao
Dec 25, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·N ImaiH Tajiri
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 1, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Michela TrioloMassimo Colombo
Oct 23, 2014·OncoTargets and Therapy·Ji-Feng FengQi Xun Chen
Oct 24, 2014·Cancers·Yan ChenPenelope Duerksen-Hughes
Oct 25, 2014·Viruses·Abigail Morales-Sánchez, Ezequiel M Fuentes-Pananá
Nov 5, 2014·Seminars in Liver Disease·Morris Sherman, Massimo Colombo
Jan 24, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wen ChenNeal D Freedman
Feb 25, 2015·Journal of Gastroenterology and Hepatology·Sung Wook YangJin-Wook Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
imaging technique

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.