Assessment of histamine-releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R AseroA Tedeschi

Abstract

All previous studies agree that only a proportion of sera from patients with chronic urticaria (CU) positive on the autologous serum skin test (ASST) are able to induce histamine release in vitro. A non-specific release of bradykinins during clotting of blood samples has been suggested; however, ASST seems rather specific and some data point to the existence of a mast cell-specific histamine-releasing factor. To assess whether, and to what extent, the use of both human basophils and mast cells increases the sensitivity of in vitro histamine release assays (HRAs) in ASST-positive patients with CU. The histamine-releasing activity of sera from 93 patients with CU selected on the basis of strong skin reactivity on ASST was assessed in vitro on basophils from 1 (n=86), 2 (n=31), or 3 (n=20) normal donors, and on mast cells from 1 (n=3), 2 (n=3), or 3 (n=87) normal donors. Sera from 88/93 (95%) patients induced significant histamine release from mast cells or basophils on at least one HRA. 76/93 (82%), 45/90 (50%), 22/80 (28%), and 6/12 (50%) sera were able to induce significant histamine release from cells of 2/5, 3/5, 4/5 and 5/5 donors, respectively. Sera from nearly all ASST-positive patients with CU are able to induce histamine...Continue Reading

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Citations

Jul 11, 2006·Current Allergy and Asthma Reports·Alexander M Marsland
Jan 31, 2009·Postgraduate Medicine·Umer Najib, Javed Sheikh
Apr 26, 2006·Expert Opinion on Emerging Drugs·Riccardo Asero, Alberto Tedeschi
Oct 31, 2007·Autoimmunity Reviews·Riccardo AseroPierluigi Meroni
Jun 24, 2006·The British Journal of Dermatology·A SzegediE Gyimesi
Apr 26, 2006·The British Journal of Dermatology·R A Sabroe, M W Greaves
Jan 9, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·Emma Guttman-YasskyEduardo Shahar
Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Jonathan A BernsteinDana Wallace
Jan 17, 2014·Journal of Korean Medical Science·Young-Min YeHae-Sim Park
Nov 14, 2013·Dermatology Research and Practice·Sujoy KhanHarpal Singh
Apr 4, 2013·International Archives of Allergy and Immunology·Rafael Rabelo-FilardiRégis A Campos
Sep 1, 2005·Current Opinion in Allergy and Clinical Immunology·Javed Sheikh
Jun 5, 2008·Journal of Food Protection·Robert BuchananUNKNOWN Threshold Working Group

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