Assessment of human pancreatic islets after long distance transportation

Transplantation Proceedings
Z YangKenneth Brayman

Abstract

Pancreatic islet transplantation can replace functional insulin-secreting beta cells for patients with type 1 diabetes. More than 300 patients who have received islet transplantation have returned to a euglycemic condition without using insulin. Therefore, islet transplantation has gained public attention and interest. Unfortunately, shortages in organ donations, suboptional antirejection regimens, and difficulties in islet isolation limit clinical utilization of this therapy. Recently, successful islet transplantation has been reported using a centralized islet isolation facility. The advantage of this experience is that it avoids the high costs in building an isolation facility and maintaining an experienced technical team. However, a private airplane carrier was required for transporting islets back to the transplantation site in a remote hospital. The cost of this specialized transportation was still too high to be considered as a routine procedure. In this study, we report our experience using commercial carriers to deliver isolated human islets from an established isolation facility to a remote medical center.

Citations

Apr 16, 2009·JAMA : the Journal of the American Medical Association·John S KaddisJoyce C Niland
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H IchiiC Ricordi
Jun 3, 2011·Journal of Diabetes·Shinichi Matsumoto
Oct 26, 2013·Transplantation Proceedings·T-S KimS-K Lee
Oct 23, 2010·Pancreas·Vijayaganapathy VaithilingamBernard E Tuch
Oct 28, 2019·Journal of Animal Physiology and Animal Nutrition·Ayman Hassan Abd El-AzizIrfan Ullah
May 13, 2006·Clinical Science·Shaheed Merani, A M James Shapiro

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