Assessment of ica operon carriage and biofilm production in Staphylococcus epidermidis isolates causing bacteraemia in bone marrow transplant recipients

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
E NininH Richet

Abstract

The clinical significance of coagulase-negative staphylococci isolated from blood culture is typically assessed on the basis of a combination of clinical and microbiological criteria. However, these criteria are difficult to apply to haematology patients who are highly immunosuppressed and from whom blood cultures are obtained most frequently through a central venous catheter. This study analysed 112 episodes of Staphylococcus epidermidis bacteraemia that occurred in 79 bone marrow transplant recipients. In 73 (65%) episodes, only one blood culture set was positive for S. epidermidis, while 39 (35%) episodes grew S. epidermidis from multiple blood cultures. Nine patients had two or more episodes of bacteraemia with the same strain, as determined by pulsed-field gel electrophoresis (PFGE). The PFGE method also showed that 34 (31%) isolates belonged to seven clusters, indicating the persistence of certain clones in the environment. Of the 109 isolates analysed, 59 (54%) produced biofilm and 91 (83.5%) carried the ica operon. Isolates that produced biofilm were observed to colonise central venous catheters faster than non-biofilm-producing isolates (18 vs. 37 days; p 0.03). No clinical features were associated with carriage of the...Continue Reading

References

Nov 1, 1990·Journal of Clinical Microbiology·M A Deighton, B Balkau
Feb 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M PfallerR M Massanari
Mar 1, 1995·Journal of Clinical Microbiology·T L BannermanJ M Miller
Aug 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Rupp, G L Archer
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L A HerwaldtM A Pfaller
Oct 1, 1996·Epidemiology and Infection·M A DeightonJ A Capstick
Oct 1, 1996·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A van BelkumH Verbrugh
Dec 1, 1996·Journal of Clinical Microbiology·F MartineauM G Bergeron
Oct 3, 1998·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J D ThyleforsD Pittet
Feb 3, 2000·Journal of Clinical Microbiology·N B FrebourgJ F Lemeland
Feb 5, 2000·The Journal of Hospital Infection·D Mack
Jul 11, 2001·Journal of Medical Microbiology·J P O'Gara, H Humphreys
Feb 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S J VandecasteeleJ Van Eldere

❮ Previous
Next ❯

Citations

Aug 8, 2008·Journal of Clinical Microbiology·Kenneth L MuldrewCharles W Stratton
May 22, 2009·Journal of Clinical Microbiology·V SivadonJ-L Gaillard
Oct 23, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I Papadimitriou-OlivgeriI Spiliopoulou
Dec 3, 2008·Blood Reviews·Leon J Worth, Monica A Slavin
Aug 26, 2017·The Open Microbiology Journal·Agostinho Alves Lima-E-SilvaEduardo Matos Nogueira
Aug 31, 2018·Osong Public Health and Research Perspectives·Maryam KordEzzat Allah Ghaemi

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.