Assessment of implementation of a standardized parenteral formulation for early nutritional support of very preterm infants.

European Journal of Pediatrics
Richard LenclenDenis Brossard

Abstract

Parenteral nutrition (PN) plays an important role in the nutritional support of very preterm newborns. It has been suggested that a high proportion of PN orders could be standardized. In 2002, we implemented in our unit the preparation of three standardized formulations for PN adapted to the nutritional requirements of premature infants<32 weeks. Following this change of practice, a retrospective observational study was conducted to evaluate the relevance of the implemented standardized PN regime. Twenty premature inborn infants<32 weeks gestation who had received standardized (STD) PN in 2003 were matched for 20 infants who had received individualized (IND) PN in 2001. Adequacy of nutrition was assessed by comparing daily intravenous nutrient intake and biochemical parameters during the first week. Amino-acid intakes on day 3 were higher in the STD group (1.5+/-0.2 g/kg/d vs. 0.9+/-0.5, p<0.001), and the calcium phosphate intakes were better balanced. The cumulated intake of amino acids for the first week was greater in the STD group (+20% ; p=0.0003). Biochemical parameters were similar in both groups. Insulin infusions were less frequent in the STD group (p<0.06). Standardized parenteral formulations provided higher early in...Continue Reading

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Citations

Jan 27, 2009·Pharmacy World & Science : PWS·Maria SkouroliakouAntonios Gounaris
Dec 4, 2012·Nutrients·Walter ZinggMaria Martin
Mar 30, 2013·Nutrients·Karen SimmerGirish Deshpande
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Dec 16, 2020·Nutrición hospitalaria·Marina Sáez-BellóSalvador Martínez-Arenas

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