Assessment of in vivo assays for endocrine disruption

Best Practice & Research. Clinical Endocrinology & Metabolism
S A Clode

Abstract

The United States Environmental Protection Agency (USEPA) has developed a screening and testing programme to detect endocrine-disrupting chemicals. This programme is organized into two phases: a tier 1 screening battery and, for those chemicals that are positive in this phase, a tier 2 testing battery. Similarly, the Organization for Economic Cooperation and Development (OECD) has set up a task force to identify, prioritize and validate test methods for the detection of endocrine disrupters. This chapter describes the mammalian in vivo assays recommended by these organizations. The tier 1 screening recommended by both agencies comprises the uterotrophic assay for the detection of oestrogens and anti-oestrogens, and the Hershberger assay for the detection of anti-androgens. Both of these assays are nearing the end of a comprehensive validation process and show consistency across testing laboratories. A further assay recommended by the USEPA is the female pubertal assay, designed to assess steroidogenesis, anti-thyroid activity and anti-oestrogenicity, while the OECD recommends an enhanced version of their standard regulatory test guideline number 407, the 28-day rat toxicity test. The tier 2 test recommended by both agencies is ...Continue Reading

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Citations

Apr 25, 2012·Analytical and Bioanalytical Chemistry·Nadia QuignotEmmanuel Lemazurier
Mar 31, 2009·Archives of Environmental Contamination and Toxicology·Giuliana G K BotelhoAnderson J Martino-Andrade
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Oct 6, 2018·Environmental Health and Toxicology·Byeonghak MoonSeung Min Oh
Dec 5, 2018·Experimental Biology and Medicine·Gismar Mc RodriguesSuzelei de Castro Franca

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