PMID: 6404550Jan 1, 1983Paper

Assessment of in vivo natural antitumor resistance and lymphocyte. Migration in mice: comparison of 125I-iododeoxyuridine with 111indium-oxine and 51chromium as cell labels

Cancer Immunology, Immunotherapy : CII
R H WiltroutR B Herberman

Abstract

Clearance of IV-injected tumor cells has been correlated with levels of natural killer (NK) cell activity in recipient animals. Studies of in vivo tumor cell clearance strongly suggest a relationship between levels of NK cell activity and antitumor or antimetastatic effector function. This study outlines the applicability of three radiolabels, [125I]iododeoxyuridine, ( [125I]dUrd), indium-111-oxine chelate ( [111In]Ox), and chromium-51 (51Cr), to studies of tumor cell clearance in vivo. The suitability of these labels for analysis of the in vivo migration patterns of normal lymphocytes or thymus-derived T cells cultivated in vitro (CTC) is also discussed. The results indicate that [111In]Ox and 51Cr compare favorably with the more widely used [125]dUrd as radiolabels for the assessment of IV-injected tumor cell clearance from the lungs of mice. The rates of clearance of both [111In]Ox and 51Cr, like that for [125I]dUrd, correlate closely with levels of NK-cell activity of the host. Further studies with [111In]Ox reveal that treatment of recipients with anti-asialo GM1 serum, a regimen known to suppress NK-cell activity, demonstrates the appropriate reduction in isotope clearance from the lungs after NK suppression. However, cle...Continue Reading

References

Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Jul 1, 1978·Journal of the National Cancer Institute·R H WiltroutG D Cummings
Jan 1, 1979·Immunological Reviews·R Kiessling, H Wigzell
Jan 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·P FrostH Frost
Jan 1, 1979·International Journal of Nuclear Medicine and Biology·H FrostJ Thrall
Jan 1, 1979·Immunological Reviews·R B HerbermanP Puccetti
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Apr 1, 1976·The Journal of Experimental Medicine·R N CahillZ Trnka
Jan 1, 1974·Advances in Immunology·J C Cerottini, K T Brunner
Oct 1, 1965·Experimental Cell Research·H O Sjögren, I Hellström
Mar 1, 1966·Transplantation·D R BainbridgeG Gowland
Apr 15, 1980·International Journal of Cancer. Journal International Du Cancer·C RiccardiR B Herberman
Jan 1, 1981·Journal of Immunological Methods·S M SparshottW L Ford
Mar 1, 1980·European Journal of Immunology·M KasaiT Tada
Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·E GorelikR B Herberman
May 15, 1981·International Journal of Cancer. Journal International Du Cancer·E Gorelik, R B Herberman
Apr 17, 1980·Nature·J E TalmadgeJ R Starkey

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Citations

Dec 29, 2007·Immunological Investigations·Joseph J SkitzkiSharon S Evans
Jun 18, 2014·ILAR Journal·Colleen M O'Connor, Heather Wilson-Robles
Jul 13, 1989·Nature·P K Horan, S E Slezak
Mar 1, 1996·Clinical & Experimental Metastasis·L Jadeski, L Hoffman-Goetz
Apr 1, 1992·Journal of Neuroimmunology·G J BrennerJ A Moynihan
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·A LockshinJ S Stehlin
Apr 1, 1984·Seminars in Nuclear Medicine·J G McAfeeG Gagne

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