Assessment of industry data on pulmonary and immunosuppressive effects of IQOS

Tobacco Control
Farzad MoazedJeffrey Gotts

Abstract

Heated tobacco products are being touted as novel reduced-harm tobacco products by tobacco companies. In the USA, Philip Morris International submitted a modified risk tobacco product (MRTP) application to the US Food and Drug Administration in 2016 in which it purports that its heated tobacco product, I-Quit-Ordinary-Smoking (IQOS), is associated with reduced harm compared with conventional cigarettes. We reviewed Philip Morris International's MRTP application to assess the pulmonary and immune toxicities associated with IQOS use in both animal and human studies. Among rats exposed to IQOS, there was evidence of pulmonary inflammation and immunomodulation. In human users, there was no evidence of improvement in pulmonary inflammation or pulmonary function in cigarette smokers who were switched to IQOS. IQOS is associated with significant pulmonary and immunomodulatory toxicities with no detectable differences between conventional cigarette smokers and those who were switched to IQOS in Philip Morris International's studies. Philip Morris International also failed to consider how dual use and secondhand aerosol exposure may further impact, and likely increase, the harms associated with these products.

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Citations

Oct 12, 2018·Tobacco Control·Jesse EliasPamela M Ling
Oct 26, 2018·Tobacco Control·Stanton A Glantz
Oct 7, 2018·Tobacco Control·Lauren Kass Lempert, Stanton A Glantz
Sep 7, 2018·Tobacco Control·Noel J LeighMaciej Lukasz Goniewicz
Jul 1, 2020·Tobacco Control·Lauren Kass Lempert, Stanton Glantz
Sep 18, 2020·BMJ : British Medical Journal·Anna B Gilmore, Sophie Braznell
Oct 3, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas D Fried, Jason D Gardner
Jun 18, 2020·Medicina·Athanasia PatakaParaskevi Argyropoulou
Feb 13, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Michael S DunbarElizabeth J D'Amico
Dec 22, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tariq A BhatYasmin M Thanavala
Apr 4, 2021·Tobacco Control·Lauren Kass LempertStanton Glantz
Apr 18, 2020·Tobacco Control·Andrew Seidenberg, Becky Freeman
Apr 7, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Carla J BergChristina N Wysota
May 27, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Fabio VivarelliMoreno Paolini
Jan 7, 2022·The Cochrane Database of Systematic Reviews·Harry Tattan-BirchJamie Brown

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Methods Mentioned

BETA
bronchoalveolar lavage
bronchoalveolar
lavage

Software Mentioned

STATA
IQOS

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