PMID: 11930884Apr 5, 2002Paper

Assessment of infarct size by positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose: a new absolute threshold technique

European Journal of Nuclear Medicine and Molecular Imaging
P ChareonthaitaweeO Rimoldi

Abstract

Along with hibernating myocardium, infarct size is a critical term in the progression of left ventricular remodelling and congestive heart failure. Both infarcted and hibernating myocardium determine changes in remote non-ischaemic tissue. This study was designed to test the accuracy of a new technique to quantify infarct size using positron emission tomography (PET) with [18F]2-fluoro-2-deoxy-D-glucose (FDG). Studies were carried out in (a) nine pigs with acute myocardial infarction (two sham-operated), produced by a 90-min occlusion of the circumflex coronary artery followed by a 4-h reperfusion, and (b) humans (six patients with ischaemic cardiomyopathy awaiting cardiac transplantation and five normal volunteers). In both animals and patients, myocardial FDG uptake was measured by PET during hyperinsulinaemic-euglycaemic clamp. Infarct size was quantified by an absolute threshold of tracer uptake obtained from the parametric (voxel-by-voxel) image of the metabolic rate of FDG. PET infarct size estimates were compared with independent ex vivo planimetric measurements of the explanted swine and patient hearts (at transplantation) after staining with triphenyltetrazolium chloride. There was good agreement between the planimetri...Continue Reading

Citations

Mar 26, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Miguel Hernandez-PampaloniPaolo G Camici
Dec 21, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andrei TodicaM Hacker
Aug 6, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ornella E Rimoldi, Paolo G Camici
Jul 7, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Juan F GranadaErling Falk
Sep 6, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Andrei TodicaSebastian Lehner
Apr 18, 2008·Current Cardiology Reports·Timm Dickfeld, Christopher Kocher
Jan 4, 2008·Circulation·Paolo G CamiciOrnella E Rimoldi
Dec 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Paul KnaapenFrans C Visser
Mar 16, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Victor Y ChengDaniel S Berman

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