Assessment of injectable and cohesive nanohydroxyapatite composites for biological functions

Progress in Biomaterials
Sai Santosh Babu KomakulaShashi Singh

Abstract

Pressing need for utilization of injectables/fillers in various forms of orthopaedic treatments/surgeries commands an equal demand for better graft material. Injectable bone graft material based on biomimetically synthesized nanohydroxyapatite was developed and subjected to ball milling for different times; three materials thus produced were evaluated for their biological properties. The three composites tested were found to have some difference in proliferation and differentiation on mesenchymal stem cells in cultures. In vivo studies were performed by implanting the graft materials with or without cells in the bone drill hole injury created in the femur of Wistar rats. Our studies show that the composites lead to well-healed injury site with normal histology without inflammation or fibrous tissue formation and bone deformity. This material needs to be tested on large animals for further ascertaining its applicability in clinical use.

References

Apr 1, 1991·Journal of Biomedical Materials Research·Y C HongL C Chow
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J LianG Stein
May 1, 1995·Calcified Tissue International·H Y ZhouY Kuboki
Jan 1, 1994·Dental Materials : Official Publication of the Academy of Dental Materials·K IshikawaK Asaoka
Jul 1, 1995·Biomaterials·Y MiyamotoK Asaoka
Jan 4, 1998·Journal of Biomedical Materials Research·Y MiyamotoK Asaoka
May 20, 1999·Journal of Biomedical Materials Research·C I ValloT R Cuadrado
Feb 5, 2000·British Journal of Plastic Surgery·I T Jackson, R Yavuzer
Dec 20, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D J VerretJesse Smith
Mar 4, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Borhane H FellahPierre Layrolle
May 12, 2006·Journal of Materials Science. Materials in Medicine·Yu ZhangLaurence C Chow
Feb 27, 2007·Journal of Materials Science. Materials in Medicine·Sergio del ValleMaria-Pau Ginebra
Aug 16, 2008·Journal of Materials Science. Materials in Medicine·L HernándezI Goñi
Oct 14, 2009·Journal of Materials Science. Materials in Medicine·Gangfeng HuPeijian Tong
Mar 17, 2012·Journal of Materials Science. Materials in Medicine·Nitin Pratap VarmaArvind Sinha

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