Abstract
To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM). 5 NGT, 25 HINS, 25 IGT, and 25 T2DM subjects participated in this research. The hyperinsulinemic-euglycemic clamp technique (HECT) was performed in all of them to evaluate IR levels. The relative factors influencing IR were evaluated. The simple insulin sensitivity indices were calculated, and the correlation between each index and the M value was analyzed. The M values of NGT, HINS, IGT, and T2DM groups were 11.88 ± 2.93 mg · kg(-1) · min(-1), 6.23 ± 1.73 mg · kg(-1) · min(-1), 6.37 ± 2.12 mg · kg(-1) · min(-1), and 6.19 ± 1.89 mg · kg(-1) · min(-1), respectively. M values in HINS, IGT, and T2DM groups were lower than those in the NGT group (P = 0.005); however, the differences among the HINS, IGT, and T2DM groups were not statistically significant (P = 0.835). The independent factors influencing the M value were waistline and fasting insulin level (FINS). The simple insulin sensitivity indices, especially Matsuda and Gutt index, were significantly associated with the M value (P < 0.01). IR existed in t...Continue Reading
References
Dec 1, 1988·Diabetes·G M Reaven
Sep 30, 1998·Diabetes·E BonoraM Muggeo
Sep 10, 1999·Diabetes Care·M Matsuda, R A DeFronzo
Jan 25, 2000·American Journal of Epidemiology·R L HansonW C Knowler
Aug 11, 2000·Diabetes Care·M PyöräläK Pyörälä
Jan 30, 2002·Diabetes·Timon W van HaeftenJohn E Gerich
Dec 3, 2002·Archives of Internal Medicine·Hanna Bloomfield RubinsJames W Anderson
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Mar 21, 2006·Metabolism: Clinical and Experimental·Nicholas P HaysWilliam J Evans
Mar 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Claudio CobelliRobert Rizza
Nov 21, 2007·Diabetes Care·Flavio E HiraiRonald Klein
May 14, 2009·Diabetes Care·Rachel DanknerJesse Roth
May 15, 2009·European Journal of Endocrinology·Susanne R de RooijUNKNOWN RISC Group Investigators
Jul 2, 2010·Diabetes Care·Fida BachaSilva A Arslanian
Nov 25, 2011·BMC Medical Research Methodology·Anwar BoraiGordon Ferns
Jan 26, 2012·Indian Journal of Endocrinology and Metabolism·Edavan P PraveenAriachery C Ammini
Aug 7, 2012·Diabetes/metabolism Research and Reviews·R DanknerJ Roth
Aug 23, 2012·Diabetologia·J J Nolan, K Færch
Nov 23, 2012·Diabetes Care·Barbara E Corkey
Dec 19, 2013·North American Journal of Medical Sciences·Mukund P SrinivasanChakrapani Mahabala
Jun 26, 2014·Surgery·Christopher T KellyWalter J Pories
Oct 21, 2014·Annals of Medical and Health Sciences Research·R BanerjeeI Nath
Citations
Oct 23, 2010·Reproductive Biology and Endocrinology : RB&E·Yan YangMei-Zhi Li
Jan 20, 2011·Reproductive Biology and Endocrinology : RB&E·Yan YangMei-Zhi Li
Jan 31, 2015·PloS One·Liying ZhangHequn Zou
Aug 16, 2018·Physiology·Cetewayo S RashidRebecca A Simmons
Dec 4, 2019·The Cochrane Database of Systematic Reviews·Kasper S MadsenBianca Hemmingsen
Jan 8, 2020·Nutrients·Tanja Tilles-TirkkonenLeila Karhunen
Jul 1, 2016·Human Gene Therapy·Sean CarrigAshley T Martino
May 15, 2018·Frontiers in Immunology·Fabiana B BenattiBruno Gualano
Mar 21, 2017·Arthritis Care & Research·Cíntia N H MiyakeFabiana B Benatti
Aug 18, 2018·Oxidative Medicine and Cellular Longevity·Akram AhangarpourMohammad Badavi
Jun 27, 2020·The Journal of International Medical Research·Yu-Peng LiHui Tian
Oct 8, 2020·Cells·Marija PetkovicLouise Torp Dalgaard
Oct 14, 2020·Journal of Food Biochemistry·Jen-Ying HsuJing-Hsien Chen
Nov 6, 2020·Physiology & Behavior·Michael D KendigKieron B Rooney
Sep 22, 2018·Medicine·Liang-Chen WangChun-Lin Li
May 1, 2021·Journal of Personalized Medicine·Marianna HallIwona Traczyk
Jul 19, 2021·Endocrinología, Diabetes Y Nutrición·Paulina E Viveros-WattyMónica Flores-Muñoz
Jul 16, 2021·The Journal of Clinical Endocrinology and Metabolism·Desiree M SigalaKimber L Stanhope