Assessment of Intestinal Failure Associated Liver Disease according to different diagnostic criteria

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Anna Simona SasdelliLoris Pironi

Abstract

Intestinal failure associated liver disease (IFALD) has been defined using numerous criteria; however the clinical relevance of these criteria has never been compared. We therefore aimed to evaluate the prevalence, incidence, evolution of IFALD diagnosed by different criteria and to assess any clinical features that may be associated with its occurrence. A cross sectional (CS) and retrospective study were carried out on adults on home parenteral nutrition (HPN) for chronic intestinal failure (CIF) managed at a single center. Inclusion criteria at CS: age ≥18 years, benign disease. Collected data included: patient demographics, CIF and HPN characteristics, episodes of central venous catheter related bloodstream infection (CRBSI). IFALD was diagnosed by 9 criteria based on liver function tests and liver ultrasound (US) imaging. IFALD diagnoses were categorized as steatosis (2 criteria), cholestasis (3 criteria) or fibrosis (2 criteria) and unclassified (2 criteria). Prevalence was assessed at CS and at starting HPN (baseline, BS). Evolution was assessed as change of IFALD between BS and CS. Incidence was calculated as patients who developed IFALD from BS to CS. A total of 113 patients were included. At CS, IFALD prevalence range ...Continue Reading

Citations

Jul 26, 2019·Alimentary Pharmacology & Therapeutics·Ashley BondSimon Lal
Jul 18, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·James MorganSimon Lal
Nov 14, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mohammad AlomariCarlos Romero-Marrero
Jan 29, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Jennifer WangDejan Micic
Feb 20, 2020·Current Opinion in Gastroenterology·Liat DeutschSimon Lal
Feb 13, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Manpreet S MundiRobert G Martindale
Nov 25, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Mohamed Tausif SiddiquiDonald F Kirby
Jan 2, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sara MassironiMaurizio Vecchi
Feb 4, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Kishore IyerSanjeev Arora
Mar 2, 2021·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Fotios S FousekisDimitrios K Christodoulou
Jul 10, 2021·World Journal of Gastroenterology : WJG·Aysegül AksanJürgen Stein

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