Assessment of Invasive Breast Cancer Heterogeneity Using Whole-Tumor Magnetic Resonance Imaging Texture Analysis: Correlations With Detailed Pathological Findings

Medicine
Eun Sook KoSeok Jin Nam

Abstract

There is no study that investigates the potential correlation between the heterogeneity obtained from texture analysis of medical images and the heterogeneity observed from histopathological findings. We investigated whether texture analysis of magnetic resonance images correlates with histopathological findings.Seventy-five patients with estrogen receptor positive invasive ductal carcinoma who underwent preoperative breast magnetic resonance imaging (MRI) were included. Tumor entropy and uniformity were determined on T2- and contrast-enhanced T1-weighted subtraction images under different filter levels. Two pathologists evaluated the detailed histopathological findings of the tumors including tumor cellularity, dominant stroma type, central scar, histologic grade, extensive intraductal component (EIC), and lymphovascular invasion. Entropy and uniformity values on both T2- and contrast-enhanced T1-weighted subtraction images were compared with detailed pathological findings.In a multivariate analysis, entropy significantly increased only on unfiltered T2-weighted images (P = 0.013). Tumor cellularity and predominant stroma did not affect the uniformity or entropy on both T2- and contrast-enhanced T1-weighted subtraction images....Continue Reading

References

Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T HasebeA Ochiai
May 31, 2001·Journal of Magnetic Resonance Imaging : JMRI·D JamesP Schmalbrock
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter Gibbs, Lindsay W Turnbull
Aug 18, 2004·Genes & Development·Deirdre A NelsonEileen White
Nov 24, 2004·Clinical Radiology·G CastellanoF Cendes
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Weijie ChenGillian M Newstead
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Fraser SymmansLajos Pusztai
Jul 8, 2010·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Balaji GaneshanKenneth A Miles

❮ Previous
Next ❯

Citations

May 5, 2017·Journal of Magnetic Resonance Imaging : JMRI·Song LiuZhengyang Zhou
Apr 30, 2020·Technology in Cancer Research & Treatment·Dong-Man YeTao Yu
Oct 25, 2016·Cancer Medicine·Jun-Long SongSheng-Rong Sun
Sep 1, 2017·Scientific Reports·Michael D NieskoskiBrian W Pogue

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

MATLAB
SAS
Picture Archiving Communication System

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.