PMID: 3760389Nov 1, 1986Paper

Assessment of left ventricular end-systolic pressure-volume relations with an impedance catheter and transient inferior vena cava occlusion: use of this system in the evaluation of the cardiotonic effects of dobutamine, milrinone, Posicor and epinephrine

Journal of the American College of Cardiology
R G McKayR C Pasternak

Abstract

The end-systolic pressure-volume relation has been postulated as a load-independent measure of cardiac contractility, but has been difficult to measure because of technical problems associated with the serial measurement of intracardiac volume over a physiologic range of ventricular loading conditions. Utilizing a multielectrode impedance catheter to assess continuous, on-line left ventricular relative volume during transient inferior vena cava occlusion, a method is described for determining the end-systolic pressure-volume relation and for assessing changes in this relation secondary to inotropic modulation. In particular, using this method, the relative inotropic properties were determined of four drugs: dobutamine, milrinone, epinephrine and an experimental cardiotonic agent (Ro 13-6438, Posicor). Left ventricular micromanometer pressure and impedance catheter volume were measured continuously in 10 open chest, anesthetized dogs and 14 pigs. Arterial pressure was altered over a range of 20 to 60 mm Hg by brief inferior vena cava constriction. A linear end-systolic pressure-volume relation was observed in pressure-volume diagrams constructed from on-line pressure and impedance catheter recordings. Administration of dobutamin...Continue Reading

Citations

Sep 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·A MarmorB Zaret
Feb 15, 2005·BMC Evolutionary Biology·Tracey N WilkinsonRoss A D Bathgate
Jun 18, 2004·Reproductive Biology and Endocrinology : RB&E·Eric S Hayes
Jun 6, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Jens-Albert BroscheitClemens-Alexander Greim
Mar 1, 1988·Journal of Cardiac Surgery·M K Pasque
Sep 13, 2000·Physiological Measurement· WhitePA, A N Redington
Apr 13, 1999·The American Journal of Physiology·C KorvaldT Myrmel
May 31, 2019·The Journal of Trauma and Acute Care Surgery·Carl A BeyerMichael Austin Johnson
Apr 21, 2006·Journal of Cardiac Failure·Daniel BurkhoffDonna M Mancini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

© 2021 Meta ULC. All rights reserved